流感病毒感染与急性心肌梗死关系的研究  

Research on relationship between influenza virus infection and acute myocardial infarction

作　　者：关秀茹[1] 马学华[1] 蒋丽鑫[1] 林春艳[1] 韩丽[1] 杜柏岩[1] 

机构地区：[1]哈尔滨医科大学附属第一医院检验科,150001

出　　处：《国际检验医学杂志》2011年第16期1800-1801,1804,共3页International Journal of Laboratory Medicine

基　　金：黑龙江省自然科学基金资助项目(D200968)

摘　　要：目的探讨流感病毒(IV)感染与急性心肌梗死(AMI)的关系。方法采用ELISA法检测74例AMI患者和77例对照组IV-A、IV-B抗体及白细胞介素-18(IL-18)、超敏C反应蛋白(hsCRP)的水平,并对冠心病危险因素进行调查。结果 AMI组IV-AIgG、IV-BIgG阳性率及IL-18、hsCRP水平均显著高于对照组,差异有统计学意义(P<0.01),且IgG水平与IL-18、hsCRP呈正相关。校正冠心病危险因素前后,IV-A和IV-BIgG阳性均与AMI有相关性。结论 IV感染可能激发或加重冠状动脉内炎性反应,IL-18和hsCRP参与AMI的病理过程。Objective To study the association between influenza virus infection and acute myocardial infarction （AMI）.Methods 74 patients with AMI（AMI group）,77 healthy controls were enrolled（control group）. For all subjects,antibodies specific for IV-A and IV-B,levels of interleukin-18 （IL-18） and hypersensitive C-reactive protein （hsCRP） were measured by ELISA. Meanwhile,the risk factors of coronary heart disease were investigated.Results The positive rates of antibodies specific for IV-A and IV-B IgG,and levels of IL-8 and hsCRP in AMI group were all significantly higher than those in control group. For AMI group,there was positive correlation between level of IgG and levels of IL-8 and hsCRP. After the adjustment of cardiovascular risk factors,IV-A and IV-B IgG antibodies were both correlated with AMI.Conclusion There could be significant correlation between influenza virus infection and AMI.IL-18 and hsCRP may be involved in the pathogenesis of atherosclerosis and myocardial infarction by inducing and accelerating coronary artery inflammation.

关 键 词：正黏病毒科 动脉粥样硬化 心肌梗死 白细胞介素18 

分 类 号：R542.22[医药卫生—心血管疾病]