活体亲属肾移植患者HLA配型配合率的分析  

Analysis of HLA typing incidence in living renal transplantation patients

作　　者：贾佳熹[1] 张小东[1] 

机构地区：[1]首都医科大学附属北京朝阳医院泌尿科,北京100020

出　　处：《国际检验医学杂志》2011年第16期1809-1810,1813,共3页International Journal of Laboratory Medicine

摘　　要：目的研究亲属肾移植供受者人白细胞抗原(HLA)配合率,为临床选择良好的供受者HLA配型提供参考。方法收集本院2006年1月至2008年5月106例亲属肾移植患者进行HLA配合率分析。结果 (1)父母供肾组:42例大于或等于HLA抗原半相合。(2)子女供肾组:2例HLA抗原半相合。(3)兄弟姐妹间供肾组:26例HLA完全相合9例,13例为半相合,其余为低于半相合。(4)其他亲属供肾组:HLA抗原配合呈多样性。(5)夫妻间供肾组:HLA配合率均小于或等于3个抗原。结论父母、子女及兄弟姐妹间的肾移植供受者HLA配合率高于其他亲属。Objective To investigate the coincidence of HLA typing between recipients and relative donors of kidney transplantation,and to afford clinical reference for donor choosing.Methods The coincidence of recipients and relative donors of 106 cases of kidney transplantation in our hospital were analyzed from January,2006 to May,2008.Results In group of parents as donors,42 recipients shared half-match HLA-A,B,DR and DQ with donors.In group of children as donors,2 recipients shared half-match HLA-A,B,DR and DQ with donors. Among 26 recipients in group of siblings as donors,9 cases shared the same HLA-A,B,DR and DQ typing with donors,13 cases were at least half-but not complete match,and others were lower than half-match or mismatch. In group of other relatives with sibship as donors,the math of HLA antigens were with diversity. In group of husbands or wifes as donors,there were at most 3 matched antigens between recipients and donors.Conclusion HLA typing incidence between the immediate family is higher than that in other relative donation.

关 键 词：HLA抗原 组织相容性试验 活体亲属肾移植 

分 类 号：R699.2[医药卫生—泌尿科学]