降钙素原在感染性疾病中的临床价值  

Clinical value of procalcitonin in infectious diseases

作　　者：蔡伟娟[1] 刘旻[1] 郑维威[1] 何建伟[1] 朱晔[1] 张丽翠[1] 菅辉玲[1] 程江[1] 

机构地区：[1]石河子大学医学院第一附属医院检验科,新疆832000

出　　处：《国际检验医学杂志》2011年第16期1822-1823,1825,共3页International Journal of Laboratory Medicine

基　　金：石河子大学医学院第一附属医院资助项目(SS2008-071)

摘　　要：目的探讨不同感染患者血清降钙素原(PCT)水平及全身感染患者治疗前后PCT的临床价值。方法分析2010～2011年本院收治的不同感染患者100例,另设对照组50例。检测治疗前后血清PCT和C-反应蛋白(CRP)水平,采用SPSS17.0进行数据分析。结果 (1)治疗前PCT、CRP水平全身感染组明显高于其余3组。(2)全身感染组合理抗菌剂治疗后,血清中PCT和CRP水平明显下降,与急性期比较差异有显著性。结论联合检测感染患者PCT、CRP水平可作为病情监测和疗效评价指标,在鉴别全身与局部感染及病毒感染时,PCT优于CRP,其能有效地发现早期重症感染,以指导临床早期用药。Objective To explore the serum levels of procalcitonin（PCT） in patients with different infectious diseases and the clinical value of PCT for the patients with systemic infection.Methods 100 cases of patients with different infectious diseases in this hospital from 2010 to 2011 and 50 healthy individuals were recruited. Serum levels of PCR and C-reactive protein（CRP） were detected and the results were statistically analyzed by using SPSS17.0.Results （1） Serum levels of PCT and CRP in systemic infection group before treatment were significantly higher than the other three groups. （2） Serum levels of PCT and CRP in systemic infection significantly descended after treatment,and the difference was statistical.Conclusion Combined detection of PCT and CRP might be used as indexes for the monitoring of pathogenetic condition and the evaluation of therapeutic effects. PCT might be more effective than CRP,when being used for the differential diagnosis of systemic and local infection,and might be effective for the diagnosis of early severe infection and for guiding the early medication.

关 键 词：C反应蛋白质 传染病 降钙素原 

分 类 号：R510[医药卫生—内科学]