探讨CCP-Ab、AKA、RF在类风湿关节炎中的诊断意义  

Diagnostic value of CCP-Ab,AKA and RF in rheumatoid arthritis

作　　者：刘斌[1] 刘春霞[1] 张虹[1] 

机构地区：[1]江苏省南通市瑞慈医院检验科,226010

出　　处：《国际检验医学杂志》2011年第16期1839-1840,共2页International Journal of Laboratory Medicine

摘　　要：目的通过检测类风湿关节炎(RA)患者血清中的风湿因子(RF)、抗角质蛋白抗体(AKA)和瓜氨酸抗体(CCP-Ab),探讨他们在RA疾病诊断中的意义。方法收集227例(RA105例,非RA82例,健康人40例)标本检测CCP-Ab,AKA及RF,并对结果进行统计学分析。结果 RF、CCP-Ab和AKA单独检测灵敏度分别为81.90%、68.57%、34.29%;特异度分别为74.39%、96.34%、95.12%;3种指标联合检测特异度为100.00%。结论 RF、CCP-Ab和AKA联合检测可提高RA诊断的特异度。Objective To evaluate the clinical value of RF,AKA and CCP-Ab in serum of patients with rheumatoid arthritis（RA）.Methods CCP-Ab,RF and AKA were detected for 105 patients with RA,82 patients with non-RA and 40 healthy controls and the results were statistically analyzed.Results The sensitivities of RF,CCP-Ab and AKA were 81.90%,68.57% and 34.29%,and the specificities were 74.39%,96.34% and 95.12%.The specificity of the combined detection were 100.00%.Conclusion The combined detection of RF,CCP-Ab and AKA could improve diagnostic specificity of RA.

关 键 词：关节炎 类风湿 类风湿因子 敏感性与特异性 

分 类 号：R593.22[医药卫生—内科学]