枸杞多糖对人卵巢癌裸鼠IGF-Ⅰ、IGFR、IGFBP-1水平干预作用的研究  

Study of lyceum barbarum polysaccharides on interventing IGF-Ⅰ,IGFR and IGFBP-1 levels of Human ovarian carcinoma in nude mice

作　　者：韦敏[1] 郑生智[1] 马红[2] 吕晔[1] 

机构地区：[1]中国科学院江苏省植物研究所,江苏南京210014 [2]南京中医药大学,江苏南京210029

出　　处：《湖南中医药大学学报》2011年第9期19-22,共4页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金资助(30973927);江苏省中科院植物所青年基金资助(200802)

摘　　要：目的研究枸杞多糖对人卵巢癌裸鼠IGF-I、IGFR、IGFBP-1水平干预的作用。方法利用卵巢癌细胞SK-OV-3腹腔种植于BABL/c雌性裸鼠建立荷人卵巢癌裸鼠腹腔种植瘤模型,观察其对人卵巢癌裸鼠的干预作用。结果模型组血清中IGF-Ⅰ水平、卵巢组织中IGFBP-1及IGFR水平与空白组差异均有统计学意义(P<0.01),显示造模成功。枸杞多糖能降低肿瘤引起的IGF-Ⅰ水平的升高,与空白组比较无统计学意义(P>0.05),与模型组比较差异有统计学意义(P<0.01);能升高由于肿瘤引起的IGFBP-1表达的下调,与空白组比较无统计学意义(P>0.05),与模型组比较差异有统计学意义,高、中剂量组(P<0.01),低剂量组(P<0.05);能降低肿瘤引起的IGFR水平的升高,与空白组比较无统计学意义(P>0.05),与模型组比较差异均有统计学意义(P<0.01)。结论枸杞多糖能降低卵巢肿瘤引起的IGF-Ⅰ、IGFR水平的上升,IGFBP-1水平的下降,对卵巢癌具有一定的抑制作用。Objective To study the effects of Lyceum Barbarum Polysaccharides（LBP）on IGF-I,IGFR and IGFBP-1 level of Human ovarian carcinoma of nude mice.Methods The nude mice models were established with SK-OV-3 transplanted into abdominal cavity of BABL/c female mice and intervention of the polysaccharides on the mice with ovarian carcinoma.Results The differences of IGF-Ⅰ level in serum and IGFBP-1and IGFR level in ovarian tissue between model group and control group were significant（P〈0.01） which showed that the modelling were successful.the polysaccharides could increase the level of IGF-I caused by the carcinoma compared with control group（P〈0.05）,with high and middle dosage group（P〈0.01） and with lower dosage group（P〉0.05）;it also could decrease the level of IGF-I compared with control group（P〉0.05） and with all model groups（P〈0.01）.Conclusion LBP can decrease the level of IGF-I and IGFR increased by the ovarian carcinoma and increase IGFBP-1 level to inhibit ovarian cancer.

关 键 词：枸杞多糖 BALB/C裸小鼠 胰岛素样生长因子1 胰岛素样生长因子结合蛋白1 胰岛素样生长因子受体 

分 类 号：R285.5[医药卫生—中药学]