瘦蛋白对摄食和能量平衡的调节及其在哺乳动物冬眠中的作用  

Roles of leptin in the regulation of food intake, energy balance and the mammalian hibernation

作　　者：邢昕[1] 杨明[1,2] 

机构地区：[1]沈阳师范大学化学与生命科学学院,沈阳110034 [2]辽宁省生物系统进化与农业生态重点实验室,沈阳110034

出　　处：《生命的化学》2011年第5期662-666,共5页Chemistry of Life

基　　金：国家自然科学基金项目(30770337);沈阳师范大学重大原创科学研究项目(2008202)资助

摘　　要：白色脂肪合成和分泌的瘦蛋白(leptin)作用于下丘脑和外周的代谢产热器官,对摄食和能量平衡起调节作用。摄食和能量平衡的失调,如瘦蛋白抵抗,可以导致肥胖等一系列生理疾病。以体内贮存的脂肪为主要能源物质越冬的冬眠哺乳动物,体重的年周期波动幅度巨大,其摄食和能量平衡调节机制可能不同于一般的非冬眠物种,育肥阶段可能存在瘦蛋白抵抗机制。本文总结了瘦蛋白调节摄食和能量平衡的作用机制以及瘦蛋白对冬眠哺乳动物育肥和冬眠的影响,为进一步研究冬眠哺乳动物的能量平衡提供参考。Leptin synthesized and secreted by white adipose tissue（WAT） plays important roles in the regulation of food intake and energy balance through the action on both hypothalamus and peripheral thermogenesis organs.Some physiological diseases such as obesity are due to the disorder of energy balance which can be induced by leptin resistance.As for the fat-storage hibernator,the body weight has severe circannual fluctuation and the mechanisms of food intake and energy balance may be different from other non-hibernation species,we suppose that leptin resistance may be involved in the fattening period.This article reviewed the roles of leptin in the regulation of food intake and energy balance and in the fatten period of mammalian hibernators,which will provide an insight for the further study of energy balance of mammalian hibernator.

关 键 词：能量平衡 瘦蛋白 中枢神经系统 冬眠 

分 类 号：S823[农业科学—畜牧学]