高密度SNP芯片及其对肉牛育种影响的研究进展  

High Density SNP Chip Impacts Beef Cattle Breeding

作　　者：张清峰[1] 秦巧梅[1] 

机构地区：[1]山东菏泽学院动物科学系,山东菏泽274015

出　　处：《中国畜牧兽医》2011年第10期122-124,共3页China Animal Husbandry & Veterinary Medicine

基　　金：菏泽学院科学研究基金项目(XY08BS12);国家科技支撑计划(2011BAD28B00-B04)

摘　　要：近年来先进的测序和基因分型技术促进了肉牛育种方法的革新。从过去低通量、耗时的限制性片段多态标记(RFLP)到如今高通量、高密度的单核苷酸多态性(SNP)标记,基因检测效率大幅提高。随着肉牛基因组序列图谱及SNP图谱的完成,基于高密度SNP标记的牛全基因组选择成了牛育种的新热点。作者立足高密度SNP芯片对肉牛育种的影响,综述高密度SNP芯片及和下一代测定技术及肉牛全基因组选择的研究进展,阐明高密度SNP芯片对多品种全基因组选择的模型的建立及准确的预测基因组育种值极其重要。Recent advancements in sequencing and genotyping technologies have promoted a rapid revolution in methods for beef cattle selection.Genotyping assays efficiency has been improved greatly,from the past restriction fragment length polymorphism（RFLP） markers that were low-throughput,time consuming to the newest high-density single nucleotide polymorphism（SNP） assays.As the cattle genome sequence map and SNP map were finished,cattle genome wide selection that was based on the high density SNP chip became a new research hot for cattle breeding.This paper that based on the high density SNP chip on beef cattle breeding effects,reviewed high-density SNP chip technology,next generation sequencing and beef cattle genome wide selection of research.The paper also elucidated the high-density SNP chip for multiple breeds model construction of genome wide selection,and show it was extremely important that accurately predicting genomic breeding value.

关 键 词：高密度SNP芯片 肉牛 全基因组选择 

分 类 号：S823.82[农业科学—畜牧学]