猪细小病毒结构蛋白VP2及其疫苗的研究进展  

Research in Structural Protein VP2 of Porcine Parvovirus and Advance in Vaccine of Porcine Parvovirus

作　　者：焦茂兴[1] 郭春和[2] 黄毓茂[2] 

机构地区：[1]宜春学院,江西宜春336000 [2]华南农业大学兽医学院,广东广州510642

出　　处：《中国畜牧兽医》2011年第10期231-234,共4页China Animal Husbandry & Veterinary Medicine

基　　金：江西省教育厅2010年度科技项目(GJJ10602)

摘　　要：猪细小病毒(porcine parvovirus,PPV)是引起母猪繁殖障碍性疾病的主要病原之一,该病毒在世界范围内广泛存在并呈地方性流行,给生猪的繁殖、发展带来了巨大的经济损失,故防制猪细小病毒病非常重要。PPV VP2蛋白是病毒粒子的主要衣壳蛋白,在体外能自我装配成病毒样颗粒,并能刺激机体产生抗PPV中和抗体,且可作为抗原转运载体,所以研究VP2对PPV新型疫苗研制至关重要。文章综述了猪细小病毒结构蛋白VP2及其疫苗的研究进展。Porcine parvovirus（PPV） is one of the important pathogens causing porcine reproductive syndrome.The virus exists everywhere in the world and epidemics locally,and it has caused a huge economic losses to the reproduce and development of porcine.As a result,it is very important to prevent PPV.The PPV VP2 protein,the major capsid protein of the PPV,can be assembled into virus-like particles,induce strong antibody responses against PPV and be used as vectors for delivery of heterologous epitopes.For these reasons,the research of the VP2 is critically important to the development of the new-type vaccine in PPV.In this paper,the newest research in structural protein VP2 of PPV and advance in vaccine of PPV were reviewed.

关 键 词：猪细小病毒 VP2蛋白 疫苗 

分 类 号：S852.659.2[农业科学—基础兽医学]