神经束植入治疗家兔腓肠肌失神经支配的疗效评价  

The Therapeutic Evaluation on Nerve Tract in Treating the Gastronemius Muscle Lost Innervations in Rabbit

作　　者：杨延军[1] 邱伟婷[1] 黄刚[1] 陈飞[1] 马立峰[1] 张子清[1] 

机构地区：[1]广东省深圳市龙岗中心医院,广东深圳518116

出　　处：《河北医学》2011年第11期1452-1456,共5页Hebei Medicine

摘　　要：目的:探讨家兔失神经支配腓肠肌神经束植入后其肌湿质量、肌肉收缩能力的变化以及乙酰胆碱酯酶含量的变化,为临床寻找检测肌肉萎缩程度方法和评价神经束植入术的疗效。方法:新西兰兔48只随机分为3组:神经植入组、神经吻合组及对照组,每组16只。分别于术后2、4、6、8、12、16、20及24周处死取两组右小腿腓肠肌作实验观察。结果:随着时间延长,神经植入组间肌湿质量逐渐增加,神经吻合组肌湿质量呈缓慢上升趋势。对照组肌湿质量呈缓慢下降趋势。神经植入组在第12周时肌湿质量开始大于神经吻合组(P>0.05)。神经植入组单肌收缩力逐渐增加,到16周时,神经植入组与对照组单肌收缩力已经没有差别。在16周前,各组胆碱酯酶含量的变化不是很明显,16周后,植入组胆碱酯酶含量明显增加。结论:神经植入较神经吻合方法具有很好的神经再生效果,具有较好的临床应用价值。Objective： To explore the change of muscle wet quality,muscle contraction ability and cholinesterase＇level after nerve tracts were implanted in gastrocnemius of rabbit denervated.To look for the method for assessing the degree of atrophy muscle atrophy and evaluate the curative effect of nerve tracts. Method： New Zealand rabbits（n=48） were randomly divided into control group（n = 16）,dialyneury group（n = 16） and neural implant group（n = 16）.2,4,6,8,12,16,20 and 24 weeks after the rabbits were operated,gastrocnemius in right crus were observed. Result： The muscle wet quality in neural implant group were increased significantly,compared with the dialyneury group.In contrast,the control group were descended.At 16 week,The level of cholinesterase in neural implant group were increased significantly,compared with the dialyneury group. Conclusion： The neural implant group have more significantly effect comparied with the dialyneury group.

关 键 词：神经骨骼肌 神经束植入 胆碱酯酶 

分 类 号：R651.3[医药卫生—外科学]