注射用藻酸双酯钠治疗高脂血症50例临床观察  

Clinical Observation of 50 Hyperlipidemia Patients Injected Polysaccharide Sulfate

作　　者：张秀海[1] 王艳玲[1] 郭爱香[1] 柳祥忠[1] 张贇[1] 郭予东[1] 

机构地区：[1]河南省安阳市安钢职工总医院神经内科,河南安阳455004

出　　处：《河北医学》2011年第11期1473-1477,共5页Hebei Medicine

摘　　要：目的:探讨注射用藻酸双酯钠(PSS)治疗高脂血症的临床疗效及安全性。方法:2007年10月至2010年10月在我科住院的急性脑梗死并确诊为高脂血症的患者102例,并按随机原则分治疗组(注射用藻酸双酯钠组)和对照组(口服苯扎贝特组)。治疗组50例:男28例,女22例,平均年龄(48.6±7.3)岁;对照组52例:男31例,女21例;平均年龄(49.1±6.9)岁。治疗组给予静滴注射用藻酸双酯钠0.1g(2mL),1次/d;对照组给予口服苯扎贝特胶囊0.23,次/d,14d为一疗程。比较两组患者治疗前后血甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,并观察出现的不良反应。结果:治疗组和对照组TC、TG、LDL-C水平治疗前分别为(5.92±0.76)、(2.11±0.41)、(3.96±0.71)和(5.89±0.78)、(2.09±0.39)、(3.92 0.63)mmoL/L,治疗后分别降至(4.63±0.67)、(1.42±0.26)、(2.87±0.45)和(5.13±0.77)、(2.07±0.33)、(3.02±0.51)mmoL/L,差异均有统计学意义(均P<0.01);HDL-C水平治疗前分别为(1.06±0.34)、(1.10±0.32)mmoL/L,治疗后分别升至(1.48±0.42)、(1.18±0.28)mmoL/L,差异有统计学意义(P<0.01);治疗组显效25例(50.00%),有效22例(44.00%),总有效率为94.00%,对照组显效18例(34.62%),有效20例(38.46%),总有效率(73.08%)差异有统计学意义(P<0.01)。治疗组和对照组中出现不良反应分别有2例(4.0%)、5例(9.6%),差异有统计学意义(P<0.05)。结论:注射用藻酸双酯钠降低TC、TG、LDL-C及升高HDL-C效果显著,不良反应少。Objective： To explore the clinical effect and its safety on hyperlipidemia through injecting polysaccharide sulfate（PSS）. Method： 102 hyperlipidemia patients determined with acute cerebral infarction in our department from Oct.2007 to Oct.2010,they were divided into treatment group（50 patients with injecting PSS,28 male and 22 female,average age 48.6±7.3） and control group（52 patients with oral administrating bezafibrate,31 male and 21 female,average age 49.1±6.9）.The treatment group patients were injected with PSS 0.1g（2mL）,once a day.The control group were treated through oral administrating bezafibrate capsules 0.2,3times/d,continuous 14 days.And then compared the TG,TC and HDL-C level of patients in two groups before and after treatment and checked untoward effect. Result： TC,TG and LDL-C level of the two groups before treatment individually were（5.92±0.76）,（2.11±0.41）,（3.96±0.71） and（5.89±0.78）,（2.09±0.39）,（3.92±0.63） mmoL/L,after treatment they was decreased to respectively（4.63±0.67）,（1.42±0.26）,（2.87±0.45） and（5.13±0.77）,（2.07±0.33）,（3.02±0.51）mmoL/L.The difference has statistical significance（P〈0.01）;HDL-C level before treatment were（1.06±0.34）,（1.10±0.32） mmoL/L,after treatment they was increased to（1.48±0.42）,（1.18±0.28） mmoL/L.The difference has the statistical significance（P〈0.01）;25 patients shown obvious effect（50.00%）,22 common effect（44.00%）,total effect rate was 94.00% in treatment group,18 patients shown obvious effect（34.62%）,20 common effect（38.46%）,total effect rate was 73.08% in control group.The difference has the statistical significance（P〈0.01）;Patients with untoward effect individually were 2（4.0%） and 5（9.6%） for the two groups.The difference has the statistical significance（P〈0.05）. Conclusion： Injecting PSS can decrease.The level of TC,TG LDL-C and increase HDL-C with obvious effect and less untoward effect.

关 键 词：藻酸双酯钠 高脂血症 苯扎贝特 

分 类 号：R589.2[医药卫生—内分泌]