蝉花菌丝体对慢性肾功能衰竭大鼠的治疗作用  

Effect of Cordyceps sobolifera Mycelium on Chronic Renal Failure in Rats

作　　者：谢炜[1,2] 郭月芳[1,2] 盛雨辰[1,2] 

机构地区：[1]中国医药工业研究总院 [2]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2011年第10期770-772,共3页Chinese Journal of Pharmaceuticals

基　　金：国家“重大新药创制”科技重大专项(2009ZX09301-007)

摘　　要：采用肾脏5/6切除和肾脏电灼建立慢性肾衰大鼠模型,考察蝉花菌丝体的治疗作用。结果表明,蝉花菌丝体的3个剂量组(0.6、1.2和2.4 g/kg)均能明显抑制肾脏5/6切除所致慢性肾衰大鼠血清中尿素氮和肌酐水平的升高,也能抑制由肾脏电灼引起慢性肾衰大鼠肌酐的升高。这提示蝉花菌丝体能有效延缓大鼠慢性肾衰的进程。Two kinds of rat model of chronic renal failure were established by 5/6 nephrectomy and electric cauterization to investigate the protective effect of Cordyceps sobolifera mycelium （CSM）. The results showed that three dosage groups （0.6, 1.2 and 2.4 g/kg） of CSM significantly inhibited the increase of serum urea nitrogen （BUN） level and creatinine （CRE） level in 5/6 nephrectomy rats and the increase of serum CRE level in electric cauterization rats. It indicated that CSM could reduce the rate of progression of chronic renal failure.

关 键 词：蝉花菌丝体 慢性肾功能衰竭 肾切除 电灼 

分 类 号：R963[医药卫生—微生物与生化药学]