营养支持对近端胃次全切除术后血浆Ghrelin水平的影响  

Effect of nutrition support on plasma ghrelin level after the proximal subtotal gastrectomy

作　　者：王海涛[1] 卢麒丞[1] 王荣朝[1] 张云[1] 许军[1] 

机构地区：[1]苏州大学附属第三医院胃肠外科,常州市213003

出　　处：《江苏医药》2011年第19期2276-2279,共4页Jiangsu Medical Journal

基　　金：常州市社会发展基金(CS2008207)

摘　　要：目的研究营养支持对近端胃次全切除术后患者血浆ghrelin水平的影响。方法选择83例行近端胃癌根治术的T1～3N0～1M0胃癌患者,根据营养支持方式将患者分为肠内营养组(A组,43例)和肠外营养组(B组,40例)。测定手术当天、术后第1、3、7、9天血浆ghrelin水平。结果两组术后第1天血浆ghrlein水平下降至最低点,分别为术前的(33.2±4.2)%和(34.1±3.7)%。术后第3天,A组血浆ghrlein水平的回升快于B组[(47.2±6.2)%vs.(38.4±5.7)%](P<0.05);至术后第9天,两组的回升幅度才相仿,分别为术前的(70.4±5.9)%和(67.1±6.3)%(P>0.05)。结论肠内营养较肠外营养更能促进近端胃次全术后患者血浆ghrelin水平的恢复。Objective To investigate the effect of nutrition support on plasma ghrelin level after the proximal subtotal gastrectomy.Methods Eighty-three patients with T_1-3N_0-1M_0 gastric cancer underwent proximal subtotal gastrectomy were divided into two groups of A（enteral nutrition,43 cases） and B（parenteral nutrition,40 cases）.Plasma ghrelin levels were determined by RIA before and on the 1st,3rd,5th,7th and 9th day after gastrectomy.Results Plasma ghrelin levels of two groups dropped to the nadir one day after gastrectomy,which were（33.2±4.2）% and（34.1±3.7）% of the values before.The recovery of plasma ghrelin levels on the 3rd day was greater in group A than that in group B[（47.2±6.2）% vs.（38.4±5.7）%]（P0.05）,which in groups of A and B was similar until the 9th day[（70.4±5.9）% vs.（67.1±6.3）%]（P0.05）.Conclusion Compared to parenteral nutrition,enteral nutrition is better in promoting compensational secretion of ghrelin after proximal subtotal gastrectomy.

关 键 词：肠内营养 肠外营养 胃次全切除术 GHRELIN 

分 类 号：R459[医药卫生—治疗学]