培哚普利、氨氯地平降压治疗对原发性高血压患者大动脉弹性的影响  

Effect of perindopril and amlodipine on arterial elasticity in patients with essential hypertension

作　　者：薄小萍[1] 陈茂华[1] 吴小庆[1] 李晓燕[1] 张常莹[1] 陆卫红[1] 鲍小京[1] 

机构地区：[1]无锡市人民医院心脏病科,214023

出　　处：《江苏医药》2011年第19期2296-2298,共3页Jiangsu Medical Journal

摘　　要：目的比较培哚普利、氨氯地平改善原发性高血压患者动脉弹性的作用。方法 78例轻中度原发性高血压患者随机均分成培哚普利组和氨氯地平组,以血压<140/90 mm Hg为降压达标,检测用药前和降压达标后4、12周的颈股脉搏波传导速度(cfPWV)。结果与治疗前比较,培哚普利组和氨氯地平组治疗后4、12周的cfPWV均明显下降[(12.9±2.3)m/s vs.(11.1±2.1)m/s、(9.6±1.7)m/s和(13.3±2.6)m/s vs.(11.4±2.2)m/s、(9.4±1.6)m/s](P<0.01)。结论运用培哚普利、氨氯地平降压达标,均能改善原发性高血压患者大动脉弹性。Objective To investigate the improvement of perindopril and amlodipine on artery stiffness in patients with essential hypertension（EH）.Methods A goal blood pressure（BP） of less than 140/90 mm Hg was set up during treating 78 patients with EH,who were randomly devided into two groups of A（39 cases,treated with perindopril） and B（39 cases,treated with amlodipine）.Carotid-femoral pulse wave velocity（cfPWV） was measured before and on the 4th and 12th week after the goal BP reached.Results Compared to before,cfPWV of group A and B was decreased on the 4th and 12th week after the goal BP reached[（12.9±2.3） m/s vs.（11.1±2.1） m/s and（9.6±1.7） m/s and（13.3±2.6） m/s vs.（11.4±2.2） m/s and（9.4±1.6） m/s]（P0.01）.Conclusion Treating EH with perindopril and amlodipine can improve arterial stiffness if BP is controlled below 140/90 mm Hg.

关 键 词：高血压病 培哚普利 氨氯地平 动脉弹性 

分 类 号：R540[医药卫生—心血管疾病]