氯吡格雷对不稳定性心绞痛患者血液学指标的影响  

Effect of Clopidogrel on Hemorrheology in Unstable Angina Pectoris

作　　者：魏朝阳[1] 王德荣[1] 韦虎[1] 漆波[1] 

机构地区：[1]903医院心内科,四川江油621700

出　　处：《川北医学院学报》2011年第5期437-439,共3页Journal of North Sichuan Medical College

摘　　要：目的:观察氯吡格雷对不稳定型冠心病心绞痛患者血流变学的影响。方法:将80例不稳定型冠心病心绞痛病人,随机分为观察组40例,对照组40例。观察组采用基础治疗加氯吡格雷75mg口服,qd,连用14天(疗程均为两周),对照组采用基础治疗2,周为一疗程。观察对比对全血粘度、血浆粘度、全血还原粘度、红细胞压积、血沉等血液学指标的影响。结果:观察组全血粘度(高切、低切值)、红细胞聚集指数、血沉、血小板聚集率和纤维蛋白原明显下降(p<0.01),对照组仅部分血液流变学指标改善。结论:氯吡格雷治疗不稳定型冠心病心绞痛能有效改善血液流变学指标。Objective：To observe the effect of clopidogrel on hemorrheology in unstable angina pectoris.Methods： Patients with unstable angina pectoris（80 cases） were randomly divided into two groups,40 patients in control group received standard treatment,40 patients in clopidogrel group were treated on the basis of general treatment,with clopidogrel（75mg taken orally daily for 14 days）.Hemorrheology index were assessed and compared before and after 2 weeks of treatment.Results： In all of hemorrheology index were significantly decreased after treatment（P0.05） In the clopidogrel group,and only part of indexes were improved in control group.Conclusions： Clopidogrel can improve hemorrheology in unstable angina pectoris efficiently.

关 键 词：氯吡格雷 心绞痛 不稳定型 

分 类 号：R543.3[医药卫生—心血管疾病]