尿液氨基末端B型钠尿肽前体与心功能不全的相关性研究  

A preliminary study on correlation between urinary N-terminal pro-B-type natriuretic peptide and severity of cardiac dysfunction

作　　者：赵沄[1] 丛燕[1] 冯磊[1] 张强松[1] 陆一鸣[2] 

机构地区：[1]复旦大学附属华东医院急诊科,上海200040 [2]上海交通大学医学院附属瑞金医院急诊科,上海200025

出　　处：《内科理论与实践》2011年第5期352-355,共4页Journal of Internal Medicine Concepts & Practice

摘　　要：目的:探讨尿液氨基末端B型钠尿肽前体(NT-proBNP)与心功能不全严重程度的相关性,探究其能否作为呼吸困难患者排除心功能不全的筛查指标。方法:以64例确诊为慢性心功能不全的呼吸困难患者建立研究组,以59例其他原因呼吸困难患者为对照组,比较尿液NT-proBNP与血浆NT-proBNP等心功能评价指标相关性及2组间尿液NT-proBNP浓度差异。结果:尿NT-proBNP与血浆NT-proBNP(P<0.000 1)、左心室射血分数(LVEF)(P<0.000 1)、左心室舒张期内径(LVEDD)(P=0.000 3)、左心室收缩期内径(LVESD)(P=0.000 5)、左心房前后径(LA)(P<0.000 1)等心功能评价指标相关,存在统计学意义。2组间尿NT-proBNP差异存在统计学意义(P<0.000 1)。结论:尿液NT-proBNP浓度反映了慢性心功能不全严重程度,适合作为社区慢性心功能不全预防性筛选的指标。Objective This study was designed to detect the urinary concentration of N-terminal pro-B-type natriuretic peptide（NT-proBNP） in patients with dyspnea and to determine whether it was related to the severity of cardiac dysfunction and could the urinary NT-proBNP be used as a screening marker for discriminating dyspnea patients caused by cardiac dysfunction from that caused by other causes.Methods Sixty-four patients with dyspnea caused by cardiac dysfunction and 59 patients with dyspnea due to other causes were enrolled in this study.Urinary NT-pro-BNP level was assessed to analyze whether it was correlated with plasma NT-proBNP level and other parameters of cardiac function.The difference in urinary NT-proBNP level between the two groups was also analyzed.Results Urinary NT-proBNP level correlated significantly with plasma NT-proBNP level（P0.000 1）,left ventricular ejection fraction（LVEF）（P0.000 1）,left ventricular end-diastolic diameter（LVEDD）（P=0.000 3）,left ventricular end-systolic diameter（LVESD）（P=0.000 5）and left atrium diameter（LA）（P0.000 1）.The difference in urinary NT-proBNP level between the two groups was statistically significant（P0.000 1）.Conclusions Urinary NT-proBNP level reflects the severity of cardiac dysfunction and can be used as a test for screening patients with chronic cardiac dysfunction in the community.

关 键 词：尿液 氨基末端B型钠尿肽前体 心功能不全 

分 类 号：R541.6[医药卫生—心血管疾病]