急性颅脑损伤患者血清白介素-8的变化及临床意义  

Changes and Clinical Significance of IL-8 in Patients with Acute Traumatic Brain Injury

作　　者：冯杰[1] 杨晓明[1] 冯贵龙[1] 张辉[1] 路长宇[2] 边艳峰[1] 

机构地区：[1]山西医科大学第一医院急诊科,030001 [2]北京市门头沟区医院

出　　处：《岭南急诊医学杂志》2011年第5期351-352,共2页Lingnan Journal of Emergency Medicine

基　　金：2010年山西省高校科研基金资助 (20101141)

摘　　要：目的:探讨急性颅脑损伤(TBI)后血清中白介素-8(IL-8)的含量变化及其意义。方法:采用ELISA法检测48例TBI患者不同时间血清IL-8含量,按GCS评分分组并与对照组比较,进行统计学分析。结果:TBI患者组IL-8在发病后24h、3天、5天的血清水平显著高于对照组(P<0.05),发病后血清IL-8水平与入院时GCS评分呈负相关。结论:IL-8参与了TBI后的病理生理过程,其测定对于评估脑损伤的严重程度和预后有重要的临床意义。Objective： To explore the changes traumatic brain injury （TBI）. Methods： The serum and the clinical significance of serum IL-8 in patients with acute content of IL-8 from 48 patients with TBI at different time after injury were measured by ELISA and grouped by GCS score, made statistical analyses compared with the control group. Results： The serum levels of IL-8 were significantly higher than those in the control group （P〈0.05）on the 24 h, 3rd,5th days after TBI. The serum levels of IL-8 were negatively correlated with the GCS scores after injury. Conclusions： IL-8 is involved in the pathological process of TBI, and the detection of the serum levels are important for evaluation of the severity of injury and predicition of outcomes.

关 键 词：颅脑损伤 白介素-8 临床意义 

分 类 号：R651.15[医药卫生—外科学]