蒙药紫花高乌头醇提物对豚鼠离体气管平滑肌的作用及机制  

Effect and mechanism of alcohol extractive from Aconitum excelsum on isolated tracheal smooth muscles in guinea pigs

作　　者：韩瑞兰[1] 常福厚[1] 肖云峰[1] 王敏杰[1] 

机构地区：[1]内蒙古医学院药学院,呼和浩特010010

出　　处：《中南药学》2011年第9期648-650,共3页Central South Pharmacy

基　　金：内蒙古自治区科技厅自然科学基金资助项目(编号:20080404MS1207)

摘　　要：目的观察蒙药紫花高乌头醇提物对豚鼠离体气管平滑肌张力的影响,探讨紫花高乌头醇提物的平喘机制。方法用离体气管环法观察紫花高乌头醇提物高、中、低3种不同剂量作用于由乙酰胆碱(Ach)预收缩的豚鼠离体气管平滑肌,观察其对平滑肌张力的影响及对Ach诱发的离体气管平滑肌收缩的量效曲线的影响。结果蒙药紫花高乌头醇提物可舒张由Ach诱发的豚鼠离体气管平滑肌收缩,且舒张作用随剂量增加而加强。紫花高乌头醇提物能使Ach诱发的豚鼠离体气管平滑肌收缩效应的量效曲线右移,最大效能降低。结论蒙药紫花高乌头醇提物对豚鼠离体气管平滑肌有舒张作用,可能与非竞争性拮抗Ach的收缩作用有关。Objective To observe the effect of alcohol extract from Aconitum excelsum on tracheal smooth muscles and its anti-asthmatic mechanism.Methods Isolated tracheal circle was used to observe the effect of Aconitum excelsum in low-dose,medium-dose,and high-dose on isolated smooth muscle tension pretreated by acetylcholine.Results Aconitum excelsum caused relaxation of the isolated tracheal smooth muscles pre-contracted by acetylcholine and the relaxation increased with the doses.Aconitum excelsum shifted the dose-response curves of acetylcholine to the right and inhibited the maximum response.Conclusion The extract of Aconitum excelsum can relax the isolated tracheal smooth muscles in guinea pigs by non-competitive antagonist acetylcholine.

关 键 词：紫花高乌头 豚鼠 离体气管平滑肌 乙酰胆碱 

分 类 号：R961[医药卫生—药理学]