硝基酪氨酸与病毒性肝炎  

Nitrotyrosine and Viral Hepatitis

作　　者：高爱武[1] 韩丽娟[1] 高淑磊 田玉静[1] 杨胜芬 郭小青[1] 

机构地区：[1]河北省保定市第二医院,071000 [2]保定市第四医院 [3]保定市传染病医院

出　　处：《职业与健康》2011年第20期2375-2376,共2页Occupation and Health

摘　　要：机体在正常代谢过程中,体内存在着自由基反应,肝脏富有丰富的线粒体,在代谢过程中可产生大量的氧自由基,肝脏又是脂质过氧化降解的主要场所。而病毒性肝炎是机体感染肝炎病毒后,以肝脏炎症和坏死病变为主的传染病,主要通过血液或体液而传播,因此肝脏发生病变、肝细胞受损时,可导致自由基代谢紊乱。自由基的增加和脂质过氧化,破坏了机体氧化/抗氧化体系的平衡,引起氧化应激的发生,在肝细胞损伤中起着十分重要的作用。硝基酪氨酸(nitrotyrosine,NT)是蛋白质硝基化损伤的特异性标志物。In the normal metabolic process,free radical reactions exists in the body.Abundant mitochondria can produce large amounts of oxygen free radicals in liver during metabolic process.While liver is the main place for degradation of lipid peroxidation.And viral hepatitis is the infectious disease manifested by inflammation and necrosis of liver after infection.It transmits mainly through blood or body fluids.Therefore,the liver lesions and liver cell damage can lead to free radical metabolic disorder.The increase of free radicals and lipid peroxidation destroy oxidative damage/antioxidant equilibrium,cause oxidative stress,and play an important role in the liver cell injury.Nitrotyrosine（nitrotyrosine.NT） is a specific marker of protein nitration injury.

关 键 词：病毒性肝炎 氧化应激 硝基酪氨酸 

分 类 号：R318.04[医药卫生—生物医学工程]