稳定性二氧化氯手消毒液的毒效应研究  

Research on Toxic Effects of Stable Chlorine Dioxide Hand Disinfectant

作　　者：李立[1] 尹晓晨[2] 胡余明[2] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100021 [2]湖南省疾病预防控制中心毒理科

出　　处：《实用预防医学》2011年第10期1963-1966,共4页Practical Preventive Medicine

摘　　要：目的研究二氧化氯手消毒剂的毒性效应,了解稳定性二氧化氯使用的生物安全性。方法采用急性经口毒性、多次完整皮肤刺激试验和亚急性毒性试验进行观察。结果本研究中昆明种雌、雄小鼠的急性经口LD50均大于5 000 mg/kg.bw;在兔多次完整皮肤刺激试验中,稳定性二氧化氯手消毒剂多次接触动物完整皮肤未引起动物皮肤刺激反应;在亚急性毒性试验中,动物经过28 d喂养后,试验各剂量组实验动物生长发育良好,体重增加正常,与正常对照组相比较,差异无统计学意义;各剂量组实验动物血常规和血生化指标与对照组比较,差异均无统计学意义;实验动物各脏器均未见明显病理改变。结论该稳定性二氧化氯手消毒剂在本次试验条件下,急性经口毒性属实际无毒级;对皮肤刺激属于无刺激性物质;也未显示对大鼠有亚急性毒性作用。提示该消毒剂的正常使用是安全的。Objective To study the toxic effects of chlorine dioxide hand disinfectant,and to know about the biosafety of using stable chlorine dioxide. Methods Acute oral toxicity,several times of skin irritation test and subacute toxicity test were conducted for the study. Results Acute oral LD50 of Kunming male and female mice was greater than 5,000 mg/kg·bw in this study.The stable chlorine dioxide hand disinfectant had no irritation to intact skin of rabbits.In the subacute toxicity test,after 28 days feeding,growth and development of animals in each dose group were good,there was no statistically significant difference compared with normal control group.The routine blood test and blood biochemical indices of animals in each dose group showed no statistically significant difference compared with the control group.The organs of experimental animals showed no obvious pathological changes. Conclusions Through acute oral toxicity test,skin irritation test,and subacute toxicity test in mice,the stable chlorine dioxide hand disinfectant belonged to actual non-toxic level substance,and non-irritant substance,and a substance with no subacute toxicity.The results suggest that the normal use of the disinfectant is safe.

关 键 词：二氧化氯 急性毒性 多次皮肤刺激 亚急性毒性 

分 类 号：R187[医药卫生—流行病学]