玉屏风散及甲型链球菌预防上呼吸道感染的微生态作用机理初探  

Study on the Microbial Mechanism of Yupingfeng San and α-Hemolytic Streptococcus Prevention of Upper Respiratory Tract Infection

作　　者：姚政[1] 徐艳琴[1] 郭剑男[1] 杨增祥[1] 邢海晶[1] 张亮[1] 

机构地区：[1]云南中医学院,云南昆明650500

出　　处：《云南中医学院学报》2011年第5期26-29,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(NO:30760296);云南省科技计划资助项目(NO:2007C017M)

摘　　要：目的:观察玉屏风散和甲型链球菌防治病原菌金黄色葡萄球菌侵袭上呼吸道,调节上呼吸道微生态平衡的情况。方法:分别对上呼吸道菌群失调小鼠灌胃给玉屏风散或灌胃给玉屏风散加口咽部滴注甲型链球菌7d,再以金黄色葡萄球菌口咽部滴注攻击3d,检测小鼠上呼吸道在不同时间点的菌群密集度、甲型链球菌数量、菌群多样性。结果:服用玉屏风散可使小鼠口咽部菌群紊乱的情况有所缓解,从而起到一定的对抗有害菌攻击的作用,口咽部定植甲链可在一定程度上增强这种作用。同时玉屏风散可对甲型链球菌的生长繁殖进行调节干预,保持其优势菌地位,进而维持上呼吸道微生态平衡。结论:可考虑采用中药治疗或微生态制剂干预的方法来对抗上呼吸道有害菌感染。Objective： To observe the situation of Yupingfeng San and a -Hemolytic streptococcus to prevent bacteria Staphylococcus aureus invasion, and to adjust micro -ecological balance ment situation in upper respiratory tract. Methods： Flora imbalance in the upper respiratory tract of mice were respectively fed to Yupingfeng or Yupingfeng San plus a -Hemolytic streptococcus by oropharyngeal infusion for 7 days. Then to attack mice by Staphylococcus aureus oropharyngeal infusion for three days. To test flora Density, a - Hemolytic streptococcus quantity, flora diversity in the upper respiratory tract flora of mice at different time points. Results ： Taking yupinfeng San can ease flora disturbance in oropharyngeal of mice and play a role against harmful bacterium attacking. Oropharyngeal colonization of Streptococcus can be enhanced this role. Yupinfeng San can adjust the growing of a - Hemolytic streptococcus, to Maintain its position of dominant bacteria and the micro - ecological balance of the upper respiratory tract. Condusions： We could consider using traditional Chinese medicine therapy or probiotics intervention to combat harmful bacterial infections of upper respiratory tract.

关 键 词：玉屏风散 上呼吸道感染 微生态 甲型链球菌 金黄色葡萄球菌 

分 类 号：R285.5[医药卫生—中药学]