天津市新婚人群血清叶酸水平现况调查及正常参考值  

Cross-sectional investigation on serum folic acid level and normal reference among newly-married population in Tianjin city

作　　者：王华[1] 李敏[1] 吕莉[1] 李宝娟[1] 赵志成[1] 李丽丽[1] 程静[1] 李喆[1] 

机构地区：[1]天津市妇女儿童保健中心检验科,300070

出　　处：《中国妇幼保健》2011年第30期4698-4701,共4页Maternal and Child Health Care of China

摘　　要：目的:描述天津市新婚人群血清叶酸水平的性别、年龄、地区和季节分布,取叶酸水平第5百分位点(P5)作为低叶酸水平,建立天津市不同年龄、不同性别血清叶酸水平的正常参考值,并根据检测结果指导叶酸补充,提高城市新婚人群对出生缺陷预防的认识,提高社会和家庭的优生意识。方法:选择2009年9月～2010年8月在天津各区婚姻登记处登记结婚的新婚夫妇作为调查对象,使用微生物培养法统一测定血清叶酸水平。结果:①男性叶酸水平显著低于女性(8.84 nmol/L vs12.21 nmol/L,P<0.001),男性叶酸缺乏率为29.96%,女性为13.54%;②男女血清叶酸水平随年龄增长而增加,但女性31岁以后差异不具有统计学意义(P=0.727);③男、女均以4郊区血清叶酸水平最高,滨海新区最低;④男性夏季和冬季叶酸水平均高于秋季,差异有统计学意义(夏vs秋P<0.001,冬vs秋P=0.027),男性其余季节间比较无统计学意义;女性叶酸水平以夏季最高,冬季最低,女性春季和秋季叶酸水平差异无统计学意义(P=0.079);⑤不同年龄、不同性别人群血清叶酸水平的正常参考值:≤25岁年龄段男女分别为≥3.74 nmol/L、≥4.91 nmol/L;26～30岁男女分别为≥3.71nmol/L、≥5.20 nmol/L;31～35岁男女分别为≥3.79 nmol/L、≥5.41 nmol/L;≥36岁男女分别为≥3.64 nmol/L、≥5.54 nmol/L。结论:天津市新婚人群血清叶酸水平在不同性别、年龄、地区、季节之间存在明显差异;通过对天津市新婚人群血清叶酸水平的研究,建立了天津市不同年龄、不同性别人群血清叶酸水平的正常参考值;应加强增补叶酸知识的宣教,定期监测血清叶酸水平,科学指导新婚男女双方及时补充叶酸,维持血清叶酸的正常水平,以保证母婴健康。Objective：To describe the sexual,age,regional and seasonal distributions of serum folic acid levels among newly-married population in Tianjin city,select the fifth centile of folic acid level as low folic acid level,construct normal references of serum folic acid levels of different ages and genders,direct supplement of folic acid according to the detection results,improve the cognition of newly-married population to the prevention of birth defect,improve eugenic consciousness of society and families. Methods：The newly-married couples were selected from marriage registration offices in Tianjin from September 2009 to August 2010 as investigation objects,methods of microorganism cultivation was used to detect serum folic acid level. Results：The serum folic acid level of men was 8.84 nmol/L,which was significantly lower than that of women（12.21 nmol/L）（P0.001）.The incidences of folic acid deficiency among men and women were 29.96% and 13.54%,respectively.The serum folic acid levels of men and women increased with age,but for women more than 31 years,there was no significant difference（P=0.727）.The serum folic acid levels of men and women in four districts were the highest,the serum folic acid levels of men and women in Binhai new district was the lowest;for men,the serum folic acid levels in summer and winter were significantly higher than that in autumn（P0.001,P=0.027）,there was no significant difference among other seasons;for women,the serum folic acid level in summer was the highest,and it was the lowest in winter,there was no significant difference between spring and autumn（P=0.079）.Normal references of serum folic acid levels of different ages and genders： men≤25 years： ≥3.74 nmol/L,women≤25 years： ≥4.91 nmol/L;men aged 26～30 years old： ≥3.71 nmol/L,women aged 26～30 years old： ≥5.20 nmol/L;men aged 31～35 years old： ≥3.79 nmol/L,women aged 31～35 years old： ≥5.41 nmol/L;men≥36 years： ≥3.64 nmol/L,women≥36 years： ≥5.54 nmol/L. Conclusion�

关 键 词：血清叶酸水平 新婚人群 现况调查 

分 类 号：R195.1[医药卫生—卫生统计学]