不同体外受精方式对胚胎玻璃化冷冻复苏的影响  

Effects of different in vitro fertilization procedures on embryo vitrification freezing-thawing

作　　者：孙丽君[1] 钱秋然[1] 王兴玲[1] 王雪梅[1] 郝大勇[1] 刘景[1] 张彩霞[1] 

机构地区：[1]郑州大学第三附属医院生殖中心,河南郑州450052

出　　处：《中国妇幼保健》2011年第30期4734-4737,共4页Maternal and Child Health Care of China

摘　　要：目的:观察常规体外受精和卵胞浆内单精子注射两种不同体外受精方式对胚胎玻璃化冷冻复苏的影响。方法:将移植冷冻复苏胚胎的患者(均为玻璃化法)分为两组。IVF组:新鲜周期采取常规体外受精方式而获得的胚胎;ICSI组:新鲜周期采取卵胞浆内单精子注射方式受精而得到的胚胎;比较两组的不孕类型、不孕原因以及冷冻复苏周期的复苏率、着床率、临床妊娠率和流产率等。结果:IVF组和ICSI组的复苏率、着床率、临床妊娠率差异无统计学意义(P>0.05),ICSI组的流产率明显高于IVF组但差异无统计学意义(P>0.05),IVF组和ICSI组原发不孕所占比例、继发不孕所占比例差异有统计学意义(P<0.05),IVF组和ICSI组男方因素不孕所占比例、输卵管因素不孕所占比例差异有统计学意义(P<0.05)。结论:ICSI不影响胚胎玻璃化冷冻周期的复苏率、着床率及临床妊娠率,ICSI后胚胎玻璃化冷冻复苏流产率有升高的趋势,ICSI体外受精方式主要用于原发不孕患者以及男方因素导致的不孕患者。Objective：To observe the effects of conventional in vitro fertilization（IVF） and intracytoplasmic sperm injection（ICSI） on embryo vitrification freezing-thawing. Methods：The patients receiving freezing-thawing embryo transfer（vitrification-recovery cycles） were divided into two groups： the embryos in IVF group were obtained by conventional IVF based on fresh cycles,while the embryos in ICSI group were obtained by ICSI based on fresh cycles;the infertile types,infertile causes and recurrence rates of freezing-thawing cycles,implantation rates,clinical pregnancy rates and abortion rates in the two groups were compared. Results：There was no significant difference in recovery rate,implantation rate and clinical pregnancy rate between IVF group and ICSI group（P0.05）;the abortion rate in ICSI group was higher than that in IVF group,but there was no significant difference（P0.05）.There was significant difference in the proportions of primary infertility and secondary infertility between IVF group and ICSI group（P0.05）.There was significant difference in the proportions of infertility induced by male factor and tubal factor between IVF group and ICSI group（P0.05）. Conclusion：ICSI does not affect the recovery rate,implantation rate and clinical pregnancy rate during embryo vitrification frozen cycles;after ICSI,the abortion rate of embryo vitrification freezing-thawing shows a increasing trend,ICSI is mainly applied for patients with primary infertility and infertility induced by male factor.

关 键 词：体外受精-胚胎移植 卵胞浆内单精子显微注射 玻璃化冷冻 

分 类 号：R715[医药卫生—妇产科学]