小鼠皮层caveolin-1蛋白表达与作业成绩的相关性  

The relationship between operation scores and the expression of caveolin-1 protein in the cortex of mice

作　　者：连永亮[1] 邹萍[2] 马依妮[1] 王秀文[1] 王佳佳[1] 韩丹女[1] 梁小峰[1] 邹伟[3] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029 [2]大连大学师范学院 [3]辽宁师范大学发展心理与教育研究中心

出　　处：《中华行为医学与脑科学杂志》2011年第10期872-874,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金资助项目（30970353）;辽宁省高校改革项目（2009141）

摘　　要：目的探讨小鼠作业成绩与皮层中caveolin-1（Cav—1）蛋白表达的相关性。方法以昆明种小鼠为实验对象，建立Y-迷宫模型，根据训练成绩将小鼠分为优良组与不良组，通过Western blot技术检测作业成绩不刚的小鼠皮层、海马中Cav-1蛋白的表达并分析与作业成绩的相关性。结果作业成绩优良组小鼠皮层中Cav-1蛋白的表达（Cav-1／β-actin为5．71±1．11），高于作业成绩不良组（Cav-1／β-actin为1．69±0．20），差异具有显著性（P〈0．01）；而优良组小鼠海马中Cav-1蛋白的表达（Cav-1／β-actin为0．22±0．09）与不良组（Cav-1／β—actin为0．26±0．04）相比，差异无显著性（P〉0．05）。结论小鼠Y-迷宫作业成绩优劣与脑内皮层中Cav-1蛋白的表达具有明显相关性。Objective To explore the relationship between operation scores and the expression of caveo- lin-1 （ Cav-1 ） protein in the cortex of mice. Methods Male Kunming mice were used and divided into two groups （excellent group and bad group） according to the training scores ＇after 4 days＇ Y-maze learning training. The expression of cav-1 protein in cortex and hippocampus of the mice with different scores were measured through Western blot technology. Results Cav-1 protein expression of excellent group（ Cav-1/β-actin was 5.71 ± 1.11 ） in the cortex was significantly higher than that of the bad group（ Cav-1/β-actin was 1.69 ± 0.20） （P 〈 0.01 ）. While there was no significant difference in the two groups in the expression of Cav-1 protein in hippocampus（P 〉 0.05 ）. Conclusion The operation scores have distinct correlation with the expression of Cav-1 protein in the cortex of mice.

关 键 词：CAVEOLIN-1 作业成绩 小鼠 皮层 

分 类 号：R285.5[医药卫生—中药学]