HBeAg阴性CHB患者pre-S_1Ag检测的意义  

The significance of pre-S_1Ag detection in sera of patients with HBeAg negative CHB

作　　者：李学俊[1] 陈忠城[1] 朱建芸[1] 徐启桓[1] 

机构地区：[1]广州中山大学附属第三医院,广州510630

出　　处：《中国卫生检验杂志》2011年第10期2489-2490,共2页Chinese Journal of Health Laboratory Technology

基　　金：广东省科技计划项目(2006B36005022)

摘　　要：目的:探讨HBeAg阴性CHB患者检测pre-S1Ag的意义。方法:收集我院感染科同时做pre-S1Ag、HBcAb-IgM及HBcDNA定量且HBsAg阳性的患者的资料160份,其中HBeAg阳性39例、HBeAg阴性121例,分析pre-S1Ag的表达与HBcAb-IgM及HBV DNA定量之间的关系。结果:HBeAg阴性CHB患者血清中pre-S1Ag检测阳性率明显低于HBeAg阳性CHB患者(P<0.05)。121例HBeAg阴性CHB患者血清中pre-S1Ag检测阳性率为35.5%,与HBc-IgM检测阳性率(38.8%)一致(P>0.05);pre-S1Ag阳性组HBV DNA检测率低于pre-S1Ag阴性组HBV DNA检测率,但两者之间的差别无统计学意义(P>0.05)。结论:pre-S1Ag可以作为反映HBV感染、复制的指标,但其在HBeAg阴性CHB患者中表达的意义待进一步研究。Objective：To investigate the significance of pre-S1Ag in sera of patients with HBeAg negative CHB.Methods： One hundred and sixty patients with CHB in the department of infectious diseases of our hospital were included.These patients were HBsAg positive including 39 HBeAg positive patients and 121 HBeAg negative patients.Moreover,preS1Ag,HBcAb-IgM and HBcDNA were assayed.The correlation between the expression of pre-S1Ag and HBcAb-IgM or HBV DNA was analyzed respectively.Results： The positive rate of pre-S1Ag in sera of HBeAg negative patients was significantly lower than that of HBeAg positive patients（P〈0.05）.Among 121 HBeAg negative patients,the positive rate of pre-S1Ag in sera was 35.5%,which was consistent with the positive rate（38.8%） of HBc-IgM in sera（P〈0.05）.Additionally,the detection rate of HBV DNA in sera of pre-S1Ag positive patients was lower than that of pre-S1Ag negative patients,but the difference between them was not statistically significant（P〈0.05）.Conclusion： Pre-S1Ag could be regarded as an indicator of HBV infection and duplication,but it should be further investigated in HBeAg negative patients.

关 键 词：PRE-S1AG CHB HBEAG阴性 

分 类 号：R512.62[医药卫生—内科学]