Plasmonic biosensors and nanoprobes based on gold nanoshells  

作　　者：XU BeiBei MA XiaoYuan RAO YanYing DONG Jian QIAN WeiPing 

机构地区：[1]State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

出　　处：《Chinese Science Bulletin》2011年第31期3234-3241,共8页

基　　金：supported by the National Natural Science Foundation of China (90923010);the National Basic Research Program of China (2010CB933902);the Promoting Project for Industrialization of Scientific Research Achievement of Regular Institutions of Higher Education in Jiangsu Province (2009-34)

摘　　要：Gold nanoshells (GNSs), consisting of a dielectric core coated with gold, have gained extensive attention as they show readily tunable optical properties and good biocompatibility. As highly sensitive and label-free optical biosensors with wide applications, GNSs have been investigated in many fields including drug delivery, immunoassay, cancer treatment, biological sensing and imaging. Taking advantage of the adjustability of the local surface plasmon resonance (LSPR) and the sensitivity of the surfaceenhanced Raman scattering (SERS) signal of GNSs, we have developed diverse applications including plasmonic biosensors and nanoprobes based on GNSs. In this review we introduce plasmonic and electromagnetic properties and fabrication methods of GNSs. We describe research progress in recent years, and highlight several applications of GNSs developed by our group. Finally we provide a brief assessment of future development of GNSs as plasmonic materials that can be integrated with complementary analytical techniques.Gold nanoshells （GNSs）, consisting of a dielectric core coated with gold, have gained extensive attention as they show readily tunable optical properties and good biocompatibility. As highly sensitive and label-free optical biosensors with wide applications, GNSs have been investigated in many fields including drug delivery, immunoassay, cancer treatment, biological sensing and imaging. Taking advantage of the adjustability of the local surface plasmon resonance （LSPR） and the sensitivity of the surfaceenhanced Raman scattering （SERS） signal of GNSs, we have developed diverse applications including plasmonic biosensors and nanoprobes based on GNSs. In this review we introduce plasmonic and electromagnetic properties and fabrication methods of GNSs. We describe research progress in recent years, and highlight several applications of GNSs developed by our group. Finally we provide a brief assessment of future development of GNSs as plasmonic materials that can be integrated with complementary analytical techniques.

关 键 词：生物传感器 纳米探针 全球导航卫星系统 电浆 黄金 表面等离子体共振 GNSS 光学性能 

分 类 号：TB383.1[一般工业技术—材料科学与工程]