3．0T磁共振弥散张量成像技术对轻度脊髓型颈椎病的诊断价值  

Diagnostic value of 3.0T magnetic resonance spectroscopy DTI in patients with mild cervical myelopathy

作　　者：由长城[1] 朱凯[2] 闫景龙[1] 关国发[1] 徐公平[1] 张志鹏[1] 赵伟[1] 

机构地区：[1]哈尔滨医科大学附属第一医院骨外四科,150001 [2]哈尔滨医科大学附属第一医院MRI科,哈尔滨市150001

出　　处：《中国脊柱脊髓杂志》2011年第10期839-842,847,共5页Chinese Journal of Spine and Spinal Cord

摘　　要：目的:评价3.0T磁共振弥散张量成像技术(diffusion tensor imaging,DTI)对轻度脊髓型颈椎病的诊断价值及可行性。方法:应用3.0T高场强磁共振DTI成像序列,观察22例健康志愿者88个节段(A组)和69例轻度脊髓型颈椎病患者(依据颈髓MRI平扫结果分B、C两组,B组39例患者,硬膜囊98个节段受压、颈髓信号正常;C组30例患者,颈髓65个节段受压、颈髓信号正常)颈髓的表观扩散系数(apparentdiffusioncoefficient,ADC)及分数各向异性值(fractional anisotropy,FA),分析3组颈髓ADC值、FA值之间差异。结果:A组(C3/C4、C4/C5、C5/C6、C6/C7)共88个节段之间ADC值及FA值差异无显著性(P>0.05),故合并88个椎体数据;A、B及C组ADC值分别为0.91±0.34、1.17±0.35及1.32±0.36,组间比较,ADC值A组最低,B组次之,C组最高(P值均<0.05);三组平均FA值分别为0.71±0.16、0.62±0.15及0.54±0.14,A组最高,B组次之,C组最低(P值均<0.05)。结论:颈髓DTI较常规MRI能够早期、准确地量化轻度脊髓型颈椎病的颈髓微结构改变,可以为临床医生更早诊断治疗轻度脊髓型颈椎病提供有利的影像学依据。Objective：To evaluate the diagnostic value and and the feasibility of 3.0T magnetic resonance diffusion tensor imaging（DTI） inspection to clinical mild cervical myelopathy.Method：22 healthy volunteers（Group A） and 69 patients with mild cervical myelopathy patients were studied with 3.0T high-field magnetic resonance DTI sequence（69 patients based on cervical MRI scan standard divided into Group B and C,39 patients of Group B：98 segments of spinal cord dural sac compression,spinal cord signal normal;30 patients of Group C：65 segments of spinal cord compression,spinal cord signal normal）.The apparent diffusion coefficient（ADC） and fractional anisotropy（FA） were measured intending to research and analyze spinal cord ADC values and FA values among the three groups.Result：The values of ADC and FA among the 88 various segments were not significant（P〉0.05） values of Group A（C3-C4,C4-C5,C5-C6,C6-C7）.Comparing among the Group A,B and C,mean ADC value of Group A was the lowest,mean FA value was the highest（P〈0.05）;and mean ADC value of group C was the highest,mean FA value was the lowest（P〈0.05）.Conclusion：Comparing with conventional MRI of cervical spinal cord,DTI could early and accurately quantify the changes of microstructure in the mild cervical myelopahty patients.Early diagnosis and treatment of dural sac compression and mild spinal cord compression myelopathy provided a more effective basis for clinicians.

关 键 词：脊髓型颈椎病 3.0T磁共振 弥散张量成像技术 分数各向异性值 表观扩散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.5[医药卫生—诊断学]