可吸收性巩膜外垫压材料的实验研究  

An experimental study on absorbable scleral buckling materials

作　　者：梁申芝[1] 万光明[1] 

机构地区：[1]郑州大学第一附属医院眼科,郑州450052

出　　处：《中国实用眼科杂志》2011年第10期1094-1096,共3页Chinese Journal of Practical Ophthalmology

基　　金：河南省杰出青年基金（512000600）

摘　　要：目的探讨聚己内酯作为可吸收性巩膜外垫压材料的可行性。方法将24只青紫兰兔随机分为4组，左眼为实验眼，将聚己内酯固定于巩膜壁行常规巩膜外垫压术；右眼为对照眼植入硅胶海绵。A、B、C、D4组分别于术后4周、8周、12周、16周行眼部B超检查，测量巩膜嵴高度；行大体标本和组织切片检查，观察植入后炎症反应情况。采用重量、分子量指标观察聚己内酯植入后4周、8周、12周、16周的降解情况。结果术后无一例发生植人物感染或脱出现象。聚己内酯外垫压材料在实验阶段内维持足够的巩膜嵴高度，平均约2．2mm。植入物周围炎症反应与硅胶海绵相近，且炎症反应不因聚己内酯降解而加剧。聚己内酯在实验阶段内仅分子量下降，而重量无明显改变。结论聚己内酯作为可吸收性巩膜外垫压材料效果确切、安全可靠，有可能成为一种新型的的可吸收性材料应用于临床。Objective To evaluate the feasibility of polycaprolactone （PCL） used for scleral buckling implants. Methods Twenty-four healthy pigmented rabbits were chosen and divided into 4 groups. The left eye of each group had PCL implants; the right eye had silicon sponge as control. The buckle heights created by implants were measured with B-scan and the eyeballs were enucleated for macroscopic and histopathological examinations to evaluate the tissue reactions 4 weeks, 8 weeks, 12 weeks and 16 weeks after surgery respectively. Weight lose, molecular weight were measured to observe the biodegradation of PCL. Results There were no complications, such as secondary infection or extrusion after operation. The buckle height created by PCL lasted for the whole follow-up period of 16 weeks. Compared with silicon sponge, tissue reactions of PCL implants were mild; the reaction did not increase in the study. The weight lose of PCL had no obvious changes; the molecular weight had decreased during the study. Conclusions PCL is effective and safe in the treatment of retinal detachment as absorbable scleral buckling materials, may be used as a new scleral buckle in the future.

关 键 词：聚己内酯 巩膜外垫压 可吸收性材料 

分 类 号：R608[医药卫生—外科学]