复方环丙沙星乳剂的研制及体外抑菌试验  

Development of compound ciprofloxacin emulsion and its inhibitory effects in vitro

作　　者：李孝文[1] 董伟[1] 陈小军[1,2] 许朝爱[2] 孙志良[1,3] 

机构地区：[1]湖南农业大学动物医学院,湖南长沙410128 [2]湖南五指峰生化有限公司,湖南浏阳411216 [3]湖南省兽药工程技术研究中心,湖南长沙410311

出　　处：《中国兽医杂志》2011年第10期79-80,共2页Chinese Journal of Veterinary Medicine

基　　金：湖南省科技重点项目(2008NK2007);长沙市科技重大专项(2009NK57)

摘　　要：为了充分发挥环丙沙星在兽医临床上的效果,克服其半衰期短和连续用药导致的不良反应,研制了一种复方环丙沙星乳剂。采用油乳剂灭活疫苗抗原缓释技术与药物乳剂制备技术相结合,将环丙沙星和乳酸TMP按5∶1比例制备成一种油乳剂,并对其性状及稳定性进行研究。用复方环丙沙星注射液作为对照,进行了该乳剂对5种细菌的体外抑菌试验。结果表明:复方环丙沙星乳剂为淡黄色、油乳状,pH值为6.3～6.6,颗粒平均大小为7.6μm,稳定性良好;复方环丙沙星乳剂对5种细菌的MIC值和MBC值显著强于复方环丙沙星注射液(P<0.01)。In order to investigate the efficiency of ciprofloxacin in clinical application and to overcome the shortcomings of the short half-life period that resulted in continuous medication, the long-acting prepa- ration of compound ciprofloxacin emulsion was successfully developed by combining the technology of the oil-emulsion inactivated vaccine antigen release with drug emulsion preparation. That is the oil emulsion was made by mixed the ciprofloxacin and trimethoprim lactic acid with the ratio of 5 ： 1. Besides, properties and stability were also studied. The compound ciprofloxacin injection was used as the control group whereas five kinds of bacteria were used for in vitro antibacterial test. The results showed that the compound ciprofloxacin emulsion, which was in a primrose yellow, oil emulsion state with pH 6.3-6.6 and 7.6 μm average particle size, owed a good stability. The MIC and MBC values for five kinds bacteria of compound ciprofloxacin emulsion was significantly greater than that of compound ciprofloxacin injection （P〈0.01）.

关 键 词：复方环丙沙星 乳剂 研制 体外抑菌效果 对照试验 

分 类 号：S859.79[农业科学—临床兽医学]