基于RBL-2H3细胞模型的双黄连注射液过敏患者血清中致敏原的个体化筛选策略  

Strategy of individualized screening of allergens in serum of patients allergic to Shuanghuanglian injection based on RBL-2H3 mast cell model

作　　者：肖颖[1] 赵玉斌[2,3] 谢雁鸣[4] 

机构地区：[1]石家庄学院,河北石家庄050035 [2]河北医科大学附属石家庄市中医院,河北石家庄050051 [3]中国中医科学院博士后流动站,北京100700 [4]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中国中药杂志》2011年第20期2799-2802,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-030)

摘　　要：双黄连注射液中致敏原的筛查是目前中药注射剂安全性评价急需解决的关键问题之一。该文回顾了双黄连注射液中致敏原的筛查技术的国内研究进展,提出了利用RBL-2H3细胞模型对双黄连注射液过敏患者血清中致敏原进行个体化筛选的原理、具体方法及步骤。Screening of allergens in Shuanghuanglian injection is now one of the key and urgently solved problems in assessment on the safety of traditional Chinese medicine injections. In this paper, the author reviewed the improtant progresses in study on Screening of allersens in shuanghuanglian injection. The principle, concrete methods and specific procedure were discussed on the strategy of individualized screening of allergens in serum of patients allergic to Shuanghuanglian injection based on RBL-2H3 mast cell model .

关 键 词：RBL-2H3细胞模型 双黄连注射液 药物不良反应 安全性评价 

分 类 号：R285[医药卫生—中药学]