补肾助孕中药对子宫内膜ICAM-1基因表达的影响  

Effect of Bushenzhuyun traditional Chinese medicine on the expression of ICAM-1 gene in endometrium

作　　者：聂树霞[1] 

机构地区：[1]山东省新泰市人民医院妇科,271200

出　　处：《中国妇幼保健》2011年第29期4606-4608,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨补肾助孕中药对多囊卵巢综合征(PCOS)不孕患者促排卵治疗后黄体中期子宫内膜细胞黏附分子-1(ICAM-1)mRNA表达的影响及意义。方法:随机给予患PCOS的不孕妇女两种不同的促排卵方案:克罗米芬(CC)/hCG或CC/hCG加服中药方案。选择促排卵周期中单卵泡成熟排卵的患者为研究对象,其中CC/hCG促排卵者26例,为A组;CC/hCG同时服用补肾助孕中药促排卵者28例,为B组;同期选择25例月经周期正常妇女作对照组,为C组。采用逆转录-聚合酶链反应技术(RT-PCR)对3组妇女黄体中期的子宫内膜ICAM-1 mRNA进行半定量分析。结果:ICAM-1 mRNA在3组妇女着床期子宫内膜均有表达,组间比较差异有统计学意义(P<0.05)。B、C组均高于A组(P分别<0.05、0.01),差异有统计学意义;B组和C组间差异无统计学意义(P>0.05)。结论:单纯CC/hCG促排卵治疗降低了子宫内膜容受性,加服补肾助孕中药后改善了子宫内膜容受性,有利于胚胎着床和临床妊娠率的提高。Objective： To explore the effect and significance of Bushenzhuyun traditional Chinese medicine on the expression of in tercellular adhesion molecule - 1 （ ICAM - 1 ） mRNA in endometrium during mid - luteal phase after ovulation induction treatment among the infertile patients with polycystic ovary syndrome （PCOS） . Methods： The infertile women with PCOS were treated with two kinds of ovula- tion induction protocols, respectively： clomiphene citrate （CC） /human chorionic gonadotropin （HCG） or CC/HCG combined with tradi- tional Chinese medicine. The patients with maturity and ovulation of single follicle during ovulation induction cycle were selected as study ob- jects, including 26 patients receiving CC/hCG for ovulation induction （ group A） and 28 patients receiving CC/HCG combined with Bushenz- huyun traditional Chinese medicine for ovulation induction （ group B） ; 25 women with normal menstrual cycle were selected as control group （ group C） . RT - PCR technique was used for semiquantitative analysis of ICAM - 1 mRNA during mid - luteal phase in the three groups. Results： ICAM - 1 mRNA expressed in endometrium during implantation period in the three groups, there was significant difference among the three groups （P 〈 O. 05 ） . The expression levels of ICAM - 1 mRNA in group B and group C were significantly higher than that in group A （P 〈 0.05, P 〈0. O1 ） ; but there was no significant difference between group B and group C （P 〉 O. 05 ） . Conclusion： Simple applica- tion of CC/HCG reduces the receptivity of endometrium during ovulation induction, additional Bushenzhuyun traditional Chinese medicine improves the receptivity of endometrium, contributes to implantation and increases clinical pregnancy rate.

关 键 词：补肾助孕中药 子宫内膜 细胞间黏附分子-1 促排卵 

分 类 号：R711.32[医药卫生—妇产科学]