基质金属蛋白酶7在肿瘤中的作用及其机制研究进展  

Research Advances in Effects and Mechanisms of MMP7 in Tumor Progression

作　　者：章冬银[1] 孙冰丽[2] 顾月清[1] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]江苏江山制药有限公司,江苏靖江214500

出　　处：《药物生物技术》2011年第5期457-460,共4页Pharmaceutical Biotechnology

摘　　要：基质金属蛋白酶(Matrix Metalloproteinases,MMPs)是与肿瘤相关的一个蛋白酶家族,这个家族拥有29个成员,它们广泛参与肿瘤细胞的生长、侵袭和转移以及血管生成过程。基质金属蛋白酶7(MMP7)由于其结构特点和生理活性,被认为是这个家族中最重要的成员之一。在MMPs广谱抑制剂临床实验均不理想的情况下,对MMP7与肿瘤关系的深入研究,有助于更好的针对MMP7的肿瘤药物的研发。文章介绍了MMP7在肿瘤生长、侵袭转移和肿瘤血管生成中相关作用机制,并对MMP7在肿瘤诊断和治疗中的最新研究进展做了简要综述。The matrix metalloproteinase （MMP） family of 29 proteases has long been associated with cancer invasion, metastasis and tumor angiogenesis by virtue of their ability to collectively degrade all components of the extracellular matrix （ ECM ）. Matrix metalloproteinase 7 （MMPT） is one of the most important proteases because of its structure and function. A vast number of MMPIs （ MMP inhibitors） have been developed in recent years. Due to the failure of these inhibitors in clinical trials, more efforts have been directed to the relationship between MMP7 and tumor, which can promote the design of MMPI. This review summarizes the role of MMP7 in tumor progression, and the application of MMP7 in tumor diagnosis and treatment.

关 键 词：基质金属蛋白酶7 肿瘤 肿瘤转移 

分 类 号：Q55[生物学—生物化学]