我院特殊人群“特殊使用”类抗菌药物应用调查  

Investigation on the Application of Antibiotics of "Special Use" Category in Special Populations in Our Hospital

作　　者：陈勇[1] 杨燕[1] 徐红青[1] 詹少卿[1] 徐勤[1] 

机构地区：[1]江苏南通市第一人民医院,南通市226001

出　　处：《中国药房》2011年第42期3943-3945,共3页China Pharmacy

基　　金：江苏南通市社会发展科技计划项目课题(s2010058)

摘　　要：目的:了解我院特殊人群"特殊使用"类抗菌药物的应用现状。方法:收集我院2010年7-8月146例使用"特殊使用"类抗菌药物患者的个人资料、用法用量及临床相关肝、肾功能指标等数据,并进行统计、分析。结果:我院"特殊使用"类抗菌药物的药物利用指数(DUI)基本合理,但用法用量还存在明显缺陷。老年患者药物用量基本未予调整,除注射用替考拉宁的DUI略有下降外,其他4种药物的DUI均呈上升趋势。临床医师对肝、肾功能不全者的用药剂量调整不重视,基本未予处置。结论:临床医师应重视"特殊使用"类抗菌药物的安全性、有效性、合理性和经济性,临床药师需围绕该类药的药动学和药效学开展有效的药学服务。OBJECTIVE： To research the status quo of clinical application of antibiotics which are classified as ＂special use＂ category for special populations. METHODS： During the period of Jul.-Aug. in 2010, 146 cases of antibiotics of ＂special use＂ category were collected and analyzed statistically in terms of demographic data, dosage and usage, clinically relevant indicators of liver and kidney function and other data. RESULTS： The DUI of antibiotics of ＂special use＂ category was reasonable basically in our hospital. However, there were still significant deficiencies in dosage and usage. The dose of drug in elderly patients had not been adjusted basically. Except that the DUI of Teicoplanin for injection declined slightly, the other 4 drugs’ DUI showed an upward trend. Clinicians did not attach importance to adjust the dose of drug in patients with liver and kidney dysfunction, and did little to deal with it. CONCLUSION： Clinical physicians should pay attention to clinical safety, effectiveness, rationality and economy of this class of antibiotics. Clinical pharmacists should focus on their pharmacokinetics and pharmacodynamics to develop pharmaceutical care.

关 键 词：特殊人群 “特殊使用”类抗菌药物 肝肾功能 用药分析 药学服务 

分 类 号：R287[医药卫生—中药学] R969.3[医药卫生—中医学]