神经外科围术期预防用抗菌药物干预效果分析  

Analysis of Intervention Effect of Perioperative Prophylactic Application of Antibiotics in Neurosurgery Department

作　　者：张晓娟[1] 陈彩萍[1] 万波[1] 罗宇芬[1] 杨敏[1] 

机构地区：[1]广东省人民医院药学部/广东省医学科学院,广州市510080

出　　处：《中国药房》2011年第42期3963-3965,共3页China Pharmacy

摘　　要：目的:评价干预措施对我院神经外科围术期预防用抗菌药物的有效性和可行性。方法:随机抽取我院神经外科干预前手术病历200份作为对照组和干预后手术病历200份作为干预组,对围术期预防用抗菌药物情况进行统计、分析。结果:选取的病历基本资料差异无统计学意义(P>0.05),具有可比性。对照组与干预组抗菌药物预防性应用率均为100%。与对照组比较,干预组预防用抗菌药物选择合理例数显著增加(P<0.01),预防用药时间合理例数显著增加(P<0.05);无指征联用例数显著减少(P<0.05),无依据换药的例数也显著减少(P<0.01)。平均预防用药时间对照组为8.5d,干预组为5.4d,干预组平均预防用药时间显著缩短(P<0.05);2组手术部位感染发生率差异无统计学意义(P≥0.05)。结论:我院实施的合理用药干预措施有效、可行,对规范神经外科围术期预防用抗菌药物起到了一定的促进作用。OBJECTIVE： To evaluate the feasibility and effectiveness of intervention measures on perioperative prophylactic application of antibiotics in neurosurgery department of our hospital. METHODS ： 200 neurosurgery cases before intervention were randomly sampled as control group and 200 neurosurgery cases after intervention were randomly sampled as intervention group. Investigation and analysis were performed in the perioperative prophylactic application of antibiotics. RESULTS： General information of medical records was comparable and had no significant difference（P〉0.05）. Utilization ratio of prophylactic application of antibiotics in two groups reached to 100%. Compared with control group, case number of rational prophylactic application of antibiotics in intervention group was significantly increased （P〈0.01）, and case number of rational prophylactic treatment duration increased significantly （P〈0.05）. Case number of drug combination without indication decreased significantly（P〈0.05）, case number of changing drugs without evidence decreased significantly （P〈0.01）. Average duration of prophylactic application of drugs was 8.5 d for control group and 5.4 d for intervention group, and average duration of prophylactic application of drugs was shortened significantly （P〈0.05）. There was no significant difference in the incidence of surgical site infection between two groups （P〉0.05）. CONCLUSION： The implementation of rational drug use interventions is effective and feasible. It contributes to promoting the rational perioperative prophylactic application of antibiotics in neurosurgery department.

关 键 词：围术期 预防用抗菌药物 干预 神经外科 

分 类 号：R969.3[医药卫生—药理学] R287[医药卫生—药学]