琥珀氯霉素的合成工艺改进  

Improvement of Synthesis of Chloramphenicol Succinate

作　　者：姜华[1] 陈蓉蓉[1] 蒲含林[1] 

机构地区：[1]暨南大学生物工程研究所,广东广州510632

出　　处：《化学反应工程与工艺》2011年第4期380-384,共5页Chemical Reaction Engineering and Technology

摘　　要：以吡啶为催化剂兼溶剂,氯霉素与琥珀酸酐为原料,考察了琥珀酸酐与氯霉素物质的量之比、酯化温度、酯化时间对反应的影响。结果表明,吡啶质量为氯霉素的10倍,当琥珀酸酐和氯霉素的物质的量之比为1.2,酯化温度为80℃,反应2h,琥珀氯霉素产率可达到68.3%,纯度达到98.5%。The effects of molar ratio of succinic anhydride to chloramphenicol, reaction temperature and reaction time on the synthesis of chloramphenicol succinate from chloramphenicol and succinic anhydride using pyridine as catalyst and solvent were investigated. The results showed that the yield of chloramphenicol succinate reached 68.3% under the conditions of mass ratio of pyridine to chloramphenicol 10, succinic anhydride to chloramphenicol 1.2, reaction temperature 80℃ and reaction time 2 h.

关 键 词：琥珀氯霉素 醋化 合成 

分 类 号：TQ426.7[化学工程] R284.3[医药卫生—中药学]