超临界CO_2流体萃取三七脂溶性成分动力学模型  

Study on the Dynamic Model with Supercritical CO_2 Fluid Extracting the Lipophilic Components in Panax notoginseng

作　　者：段贤春[1] 汪永忠[1] 章俊如[1] 罗欢[1] 张恒[1] 夏伦祝[1] 

机构地区：[1]安徽中医学院第一附属医院/国家中医药管理局中药制剂三级实验室,安徽合肥230031

出　　处：《中药材》2011年第8期1280-1285,共6页Journal of Chinese Medicinal Materials

基　　金：安徽省中医药管理局中医药科研课题(2009ZY01);安徽中医学院临床科学研究基金项目(2008LC1-008A);康缘中医药科技创新基金项目(KYCX201011)

摘　　要：目的:建立超临界CO2流体萃取三七脂溶性成分的动力学模型,优化萃取工艺。方法:对超临界CO2流体萃取三七脂溶性成分的过程进行数值模拟,运用质量守恒微分方程建立动力学模型,Mathmatica 6.0数学软件为数值模拟平台,对模型进行计算预测,并与实验结果比较。结果:建立了超临界CO2流体萃取三七脂溶性成分的动力学模型,模型预测结果与实验过程基本吻合,反映的趋势也与实验结果相一致,将前期实验萃取工艺参数中萃取时间由2.0 h优化为1.0 h。结论:该模型能较好地阐明三七脂溶性成分在萃取过程中的溶解传质机理,反映实际萃取过程,同时也为超临界CO2流体萃取工艺的优化和工业化放大提供了一定的理论指导。Objective：To establish a dynamics model for extracting the lipophilic components in Panax notoginseng with supercritical carbon dioxide（CO2）.Methods：Based on the theory of counter-flow mass transfer and the molecular mass transfer between the material and the supercritical CO2 fluid under differential mass-conservation equation,a dynamics model was established and computed to compare forecasting result with the experiment process.Results：A dynamics model has been established for supercritical CO2 to extract the lipophilic components in Panax notoginseng,the computed result of this model was consistent with the experiment process basically.Conclusion：The supercritical fluid extract dynamics model established in this research can expound the mechanism in the extract process of which lipophilic components of Panax notoginseng dissolve the mass transfer and is tallied with the actual extract process.This provides certain instruction for the supercritical CO2 fluid extract＇s industrialization enlargement.

关 键 词：超临界CO2流体 三七脂溶性成分 动力学模型 传质 

分 类 号：R284.2[医药卫生—中药学]