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作 者:彭耀荣[1] 李文滨[1] 褚忠华[1] 梁明娟[1] 林青[1] 王捷[1]
机构地区:[1]中山大学附属孙逸仙纪念医院肝胆外科,广州510120
出 处:《中华实验外科杂志》2011年第11期1887-1889,共3页Chinese Journal of Experimental Surgery
摘 要:目的观察大鼠同种骨髓间充质细胞(BMSCs)经门静脉肝内移植对80%肝切除肝衰竭模型术后肝功能、生存率的影响。方法通过80%肝切除建立大鼠边缘肝衰竭模型,经门静脉输注绿荧光蛋白(GFP)标记的第5代(P5)大鼠同种MSC,观察BMSCs肝内移植对肝大部分切除边缘肝衰竭模型术后生存率、肝功能的影响。结果术后7d内的存活率:MSC组72.2%(13/18)、对照组44.4%(8/18)。MSC组的存活率明显高于对照组(72.2%比44.4%,P〈0.05;MSC组大鼠术后肝功能恢复情况明显优于对照组(P〈0.05);MSC组肝组织中可观察到移植的细胞。结论经门静脉的BMSCs移植可促进80%肝切除边缘肝衰竭大鼠的肝功能恢复和提高生存率。Objective To investigate the effect of liver function and survival rate on allogeneic bone mesenchymal stem cells (BMSCs) transplantation through portal vein in the rat 80% hepatectomy model. Methods Build up the edge of limit hepatectomy rat model, transplant the 5th passage (P5) allogeneic rat BMSCs marked with green fluorescent protein ( GFP), observe the effect of liver function and survival rate after allogeneic BMSCs transplantation through portal vein in the rat hepatectomy model. Resuits Survival rate after 7 days : MSC Group 72. 2% ( 13/18), control Group 44.4% (8/18), The survival rate of MSC Group was significantly higher than control Group (72. 2% vs. 44. 4%, P 〈 O. 05 ) ; the liver function recovery after surgery of MSC Group is better than control Group ( P 〈 0. 05 ) ; transplanted BMSCs could be deteced in recipient liver of MSC Group. Conclusion BMSCs transplanted though portal vein can promote liver function recovery and improve survival rates in rat 80% hepatectomy model.
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