Silicon mediated synthesis and selected transformations of β-chloroketones  

作　　者：Tarek A.Salama Saad S.Elmorsy 

机构地区：[1]Chemistry Department,Faculty of Science,Mansoura University,35516 Mansoura,Egypt [2]Chemistry Department,Faculty of Education,Amran University,Amran,Yemen

出　　处：《Chinese Chemical Letters》2011年第10期1171-1174,共4页中国化学快报（英文版）

摘　　要：A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN_3 as well as with nitriles utilizing TCS-ZnCl_2 to give 1,5-disubstituted tetrazole derivatives orβ-amido ketones respectively are also described.A combination of tetrachlorosilane（TCS） and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination ofα,β-unsaturated ketones to afford the correspondingβ-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN_3 as well as with nitriles utilizing TCS-ZnCl_2 to give 1,5-disubstituted tetrazole derivatives orβ-amido ketones respectively are also described.

关 键 词：TETRACHLOROSILANE PHENOL β-Chloroketones Synthesis TETRAZOLES β-Amido ketones 

分 类 号：O621.2[理学—有机化学]