表皮角质分化过程中的信号转导  

Signaling pathways associate with epidermal keratinocytes differentiation

作　　者：刘雄昊[1] 张译[2] 刘慕君[1] 刘艳平[1] 

机构地区：[1]中南大学生物科学与技术学院,湖南长沙410013 [2]中南大学基础医学院,湖南长沙410013

出　　处：《中国现代医学杂志》2011年第18期2139-2143,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金青年基金资助项目(No:30900801)

摘　　要：表皮是人体的第一道防护屏障,对维持机体内环境的稳定起到了巨大的作用。表皮是新陈代谢频率较快的组织,正常机体中表皮的增殖、分化和凋亡处于一种动态的平衡中,一旦这种平衡失调,将会导致严重的皮肤病,因此,机体内应有一套精密的调控系统来调控这一过程。Notch、TGF-β和钙离子等信号通路可能参与了表皮的分化。The epidermis constitutes the outer layer of the skin and acts as a protective barrier between the body and the environment. Skin undergoes fast self-renewal throughout life to maintain the homeostasis of body＇s internal environment. Its proliferation, differentiation and apoptosis stay in. a dynamic balance. If the balance is broken, it will result in skin diseases, so the body should have a complex and exact control system to regulate this process. Recent advances suggests that several signaling pathways are associated with epidermal terminally differentiated keratinoeytes.

关 键 词：表皮分化 信号通路 NOTCH TGF-Β 钙离子 

分 类 号：R34[医药卫生—基础医学]