楂葛降脂袋泡茶剂对非酒精性脂肪肝大鼠肝脏形态学改变的影响  

The effect of Zhage reduced-fat teabags on morphological changes of the experimental nonalcoholic fatty liver disease in rats

作　　者：黄孟君[1] 曹永常[2] 周薪蓓[1] 余敏[2] 李俊贤[2] 姚军[2] 余红运[2] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学,硕士研究生湖南长沙410208

出　　处：《中医药导报》2011年第10期25-28,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省研究生科研创新基金项目(CX2010B352)

摘　　要：目的:观察楂葛降脂袋泡茶剂对实验性非酒精性脂肪肝肝脏形态学改变的影响,为临床治疗非酒精性脂肪肝提供实验依据。方法:采用高脂饮食喂饲大鼠复制脂肪肝模型,实验分组为模型组、降脂通络组和楂葛降脂袋泡茶剂高、中、低剂量组和正常对照组。以楂葛降脂袋泡茶剂高、中、低剂量和降脂通络软胶囊进行干预,各组大鼠肝脏取材,常规HE染色,光镜观察。结果:模型组均可见弥漫性肝细胞脂肪变性,主要为大泡性脂肪变性,也有部分小泡性脂肪变性,并可见大量炎性细胞浸润;楂葛降脂袋泡茶剂组为正常肝组织。仅高倍镜下可见少量肝细胞有小空泡样变。结论:楂葛降脂袋泡茶剂对非酒精性脂肪性肝病有较好的预防和治疗作用。可在一定程度上防止肝脏脂肪过度沉积,改善肝功能,改善肝细胞脂肪变性、减轻肝组织炎症。Objective To eplore the effect of Zhage reduced-fat teabags（ZhaGe） On morphological changes of the experimental nonalcoholic fatty liver disease in rats and provide the experimental basis for the clinical therapy of nonalcoholic fatty liver disease.Methods The animal model of fatty liver was duplicated with high fat diet and was randomly divided into model group,Lipid-lowering tongluo soft capsule group,high dose ZhaGe group,middle dose ZhaGe group,low dose ZhaGe group,and normal control group.All the treatment groups were intervened by its own medicine.Liver tissue was extracted and made HE staining,then observed by optical microscope.Results Model group are visible diffuse hepatic steatosis,mainly for the big bubble sex steatosis,some small bubble sex steatosis,and note the amount of inflammatory cells infiltrating;ZhaGe group for normal liver tissue.At higher magnification,only a small amount of liver cells have small empty bubble kind change.Conclusion Zhage reduced-fat teabags to nonalcoholic fatty liver disease sex has good prevention and treatment effect.But in the certain degree to prevent liver fat deposition,improve liver function,excessive improve hepatic steatosis,reduce the liver tissue inflammation.

关 键 词：非酒精性脂肪肝 楂葛降脂袋泡茶剂 大鼠 肝组织 病理组织学 

分 类 号：R256.4[医药卫生—中医内科学]