外源性激肽原酶对短暂全脑缺血的成年大鼠视网膜病理形态改变  

Histopathological changes of transient cerebral ischemia in rats with exogenous kallikrein

作　　者：吴兴萍[1] 郭露萍[1] 沙翔垠[1] 宋莉[1] 简旻[2] 曾敏怡[2] 

机构地区：[1]广州医学院第二附属医院,广东广州510260 [2]广州医学院,广东广州510260

出　　处：《中国医学工程》2011年第9期4-6,共3页China Medical Engineering

基　　金：广州市医药卫生科技项目(2009-YB-156)

摘　　要：目的观察外源性激肽原酶对成年大鼠短暂全脑缺血模型视网膜的病理形态改变,为其在眼科方面的临床应用提供依据。方法大鼠随机分为激肽原酶治疗组、短暂全脑缺血组、假手术对照组3个组,前两组分别从尾静脉注射人组织激肽原酶(1.6×10-2PNAU/Kg体重)和同样体积生理盐水10d后,观察病理形态改变。结果短暂全脑缺血组显示视网膜血管不同程度充血,视网膜节细胞层少数细胞胞浆空泡变性,激肽原酶治疗组较短暂全脑缺血组有所改善。结论激肽原酶作为一种选择性脑微小血管扩张剂,有可能改善短暂全脑缺血后视网膜微循环病变,从而避免视功能损害。【Objective】 To observe the histo pathological changes of the whole retinal vasculature in rats of transient cerebral ischemia with Exogenous kallikrein.In order to furnish some evidence for clinic Ophthalmology.【Methods】 They were randomly divided into 3 groups：exogenous kallikrein treated group,ischemia group,sham operation group,exogenous kallikrein（1.6×10-2PNAU/Kg） and the same dose of saline were given daily through caudal vein injection for 10 days in exogenous kallikrein treated group and ischemia group respectively,then the histopathology were examined with each group.【Results】 Radial incomplete perfusion showed that retinal vasculation and cytoplasmic vacuolation was localized within ganglion cell layer of the retina.The above changes had improved in exogenous kallikrein treated group than ischemia group.【Conclusion】 As a selective cerebral capillary vasodilator,Exogenous kallikrein had possibly improved injured retina of transient cerebral ischemia in rats.It help us to prevent from visual dysfunction.

关 键 词：短暂全脑缺血 视网膜损伤 动物模型 外源性激肽原酶 

分 类 号：R322.91[医药卫生—人体解剖和组织胚胎学]