Nasopharyngeal carcinoma:Advances in genomics and molecular genetics  

作　　者：ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan 

机构地区：[1]Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education of China, Central South University, Changsha 410078, China [2]Key Laboratory of Carcinogenesis of Ministry of Health of China, Central South University, Changsha 410078, China [3]Disease Genome Research Center, Central South University, Changsha 410078, China [4]Cancer Research Institute, Central South University, Changsha 410078, China [5]Xiangya Hospital, Central South University, Changsha 410078, China

出　　处：《Science China(Life Sciences)》2011年第10期966-975,共10页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.30871282,30871365,30971147,81000883,81000972,81071644,81071686,81071756,81171930,81171931,81171934,81171988,81172189,81101509,and 81102065);the 111 Project (Grant No.111-2-12);the Natural Science Foundation of Hunan Province (Grant Nos.10JJ7003,11JJ1013,11JJ22043 and 11JJ4072);the Fundamental Research Funds for the Central Universities

摘　　要：Nasopharyngeal carcinoma （NPC） is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution, being of high prevalence in southern China but rare in other parts of the world [2]. Familial clustering of NPC has been observed in diverse populations [3]. Elevated levels of circulating free Epstein-Barr virus （EBV） DNA and EBV-related antibodies in sera, as well as EBV DNA in tumor ceils, have been consistently detected in individuals with NPC [4,5].Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2].

关 键 词：鼻咽癌 分子遗传学 基因组学 全国人民代表大会 病毒DNA EB病毒 鳞状细胞癌 地域分布 

分 类 号：Q786[生物学—分子生物学] Q75