纳米人工骨植骨材料治疗胫骨平台骨折的特点  

Characteristics of nano-artificial bone graft in treatment of tibial plateau fracture

作　　者：曹阳[1] 袁子明 闫鹏[1] 毕云龙[1] 

机构地区：[1]辽宁医学院附属第一医院骨科,辽宁省锦州市121000 [2]辽宁省黑山县第一人民医院骨科,辽宁省黑山县121400

出　　处：《中国组织工程研究与临床康复》2011年第38期7189-7192,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：辽宁省卫生厅医学高峰建设项目(2010071)~~

摘　　要：背景:胫骨平台骨折复位后常遗留较大的松质骨缺损,需要有效的植骨填塞和内固定治疗。目的:探讨运用纳米人工骨植骨治疗胫骨平台骨折的应用特点。方法:由作者采用电子检索的方式,在万方数据库(http://www.wanfangdata.com.cn/)中检索,以"纳米人工骨,胫骨,骨折"为中文关键词,计算机检索1990-01/2010-12有关纳米人工骨植骨治疗胫骨平台骨折的文章,经检索共查到相关文献48篇,筛选纳入20篇文献进行评价。同时对采用纳米人工骨植骨结合锁定板内固定治疗胫骨平台骨折患者42例进行回顾性分析。结果:纳入分析的42例患者,随访6个月～2年6个月,平均15个月,骨折愈合时间3～8个月,平均4.2个月。按Merchant评分标准,其中优39例,良2例,可1例。检索分析表明纳米人工骨是应用纳米技术制备的生物材料,是一种理想的骨修复材料。人工植骨材料治疗胫骨平台骨折,能有效避免骨折再移位和关节面高度的丢失,与宿主生物相容性好,骨传导性好,无排斥、过敏反应,创伤小,固定牢固等优点,具有广泛的应用前景。BACKGROUND：After resetting,tibial plateau fracture always induces great defects of cancellous bone,which requires effective bone graft packing and internal fixation treatment.OBJECTIVE：To explore the application characteristics of nano-artificial bone graft in treatment of tibial plateau fracture.METHODS：We retrieved Wanfang Database（http：//www.wanfangdata.com.cn/） for articles concerning nano-artificial bone graft in treatment of tibial plateau fracture published from January 1990 to December 2010.The key words were ＂nano-artificial bone,tibia,fracture＂.A total of 48 articles were searched,and 20 were included.Simultaneously,42 tibial plateau fracture cases undergoing nano-artificial bone graft combined with internal fixation with locking plate system were retrospectively analyzed.RESULTS AND CONCLUSION：A total of 42 patients were followed up for 6 months to 2 years and 6 months,averagely 15 months.The duration of fracture healing was 3-8 months,averagely 4.2 months.According to Merchant criteria,there were excellent in 39 cases,good in 2 cases,and average in 1 case.Retrieval analysis suggests that nano-artificial bone is a biomaterial prepared by nanometer technique,and is an ideal bone repair material.Artificial bone graft for treatment of tibial plateau fracture can effectively avoid fracture redisplacement and the loss of articular surface height,as well as have characteristics of good biocompatibility,good bone conductibility,small trauma and firm fixation,no rejection or allergic response.Thus,it has extensive application prospect.

关 键 词：纳米人工骨 骨修复材料 生物相容性 锁定板 胫骨平台骨折 

分 类 号：R318[医药卫生—生物医学工程]