缓释药物的研究进展及临床应用  

Research progress and clinical application of sustained-release drugs

作　　者：艾合买提江[1] 于永福[2] 黄相增[3] 

机构地区：[1]新疆医科大学第六附属医院内一科,新疆维吾尔自治区乌鲁木齐市830000 [2]新疆医科大学第五附属医院ICU科,新疆维吾尔自治区乌鲁木齐市830011 [3]新疆医科大学第二附属医院内二科,新疆维吾尔自治区乌鲁木齐市830028

出　　处：《中国组织工程研究与临床康复》2011年第38期7193-7196,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:各种制备缓释制剂的缓释材料很多,目前可用于生产的缓释材料有40多种,广泛应用于临床多种疾病的治疗。目的:对目前国内外几种重要的缓释药物载体材料及临床上常用的缓释药物进行总结。方法:应用计算机检索CNKI和PubMed数据库2000-01/2010-12关于缓释药物研究的文章,在标题和摘要中以"缓释,药物,生物材料"或"sustained release,drug,biomaterials"为检索词进行检索。选择文章内容与缓释药物密切相关的文章。排除Meta分析及重复性研究,最终纳入23篇文献进入结果分析。结果与结论:可生物降解的合成高分子材料受到普遍重视并得到广泛应用,壳聚糖以其良好的性能备受青睐,成为药物缓释的一种重要载体,生物降解高分子聚乳酸在药物缓释方面的应用,起到重要的治疗作用;纤维蛋白胶生物相容性高,能有效延缓药物释放,在临床很多领域广泛应用。BACKGROUND：Currently,there are over 40 kinds of slow-release materials available for the production,which are widely used in clinic.OBJECTIVE：To review several important drug carrier materials in the world as well as sustained-release drugs commonly used in clinic.METHODS：A computer search of CNKI and PubMed databases（2000-01/2010-12） were conducted for articles addressing sustained-release drugs.The keywords were ＂sustained release,drug,biomaterials＂ in Chinese and English.Meta analysis and repetitive studies were excluded.Finally,23 articles were included in result analysis.RESULTS AND CONCLUSION：Biodegradable synthetic polymer materials have become highly valued and widely used.Chitosan has become widely accepted for its good performance,as an important carrier of drug delivery;polylactic acid,a biodegradable polymer,plays an important treatment role in drug delivery;fibrin glue with high biocompatibility can effectively delay the drug release,which is widely used in many clinical areas.

关 键 词：药物载体 缓释材料 生物降解 壳聚糖 纳米纤维 纤维蛋白 

分 类 号：R318[医药卫生—生物医学工程]