CRRT对ICU中MODS患者细胞因子和与CRRT相关脏器功能的影响  

The Influence of CRRT to the MODS ICU in Cell Factors and CRRT Related Viscera Function

作　　者：李涌泉[1,2] 张欣洲[1,2] 张万帆[1,2] 王向阳[1,2] 王康[1,2] 郭宝春[1,2] 

机构地区：[1]深圳市人民医院 [2]暨南大学第二临床医学院肾内科,深圳518020

出　　处：《中国医药导刊》2011年第7期1183-1184,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探究连续肾脏替代疗法(CRRT)对ICU中多器官功能障碍综合征(MODS)患者的IL-6、TNF-α和肝肾功能的影响。方法:随机选取我院因MODS入院患者43位,年龄在30～58岁。并按照两种不同疗法,将患者分成两组,为其中24位患者进行连续肾脏替代疗法(CRRT),而另外19位患者进行传统疗法——间歇性透析(IHD),观察肾脏各项指标,以及IL-6、TNF-α动态变化。比较两种疗法对两组患者的疗效以及与患者未治疗前身体状况进行比较。结果:运用CRRT较传统疗法更为有效。使用CRRT的患者存活率相对高、死亡率较低。肌酐(SCr)、血清尿氮(BUN)呈明显下降趋势,同时细胞因子中IL-6、TNF-α明显下降。两组比较,差异有统计学意义(P<0.05)。结论:CRRT是一项可以有效缓解、稳定MODS患者病情、并治疗MODS患者的疗法。Objective：Explore the influence of RCCT to the MODS of ICU in cell factors and CRRT related Viscera function. Methods：Selected at random from hospital who came to the hospital.The age of patients between 30 to 58.Conduct CRRT on 24 patients among them,while others were conduct traditional therapy IHD.According to two different therapy, patients were divided into two groups.Comparing the two kinds of therapies＇ effect on two groups patients and therapy body＇ s c0ndifiun,Resulits：CRRT increase the survival of these patient and reduce the death of people.It is found that blood urea nitrogen show clear downtrend after using CRRT.IL- 6,TNF-α obviously decreased, SCr and BUN decrease obviously, there is statistical significance（P〈0.05）,Conclusion：CRRT is affective way to remit and steadies symptom of MODS patients, also can treat MODS.

关 键 词：连续肾脏替代疗法(CRRT) 多器官功能障碍综合征(MODS) 细胞因子 脏器功能 

分 类 号：R459.5[医药卫生—治疗学] R692.5[医药卫生—临床医学]