血小板衍化内皮细胞生长因子在胃癌中的表达及其预后意义  

Expression and Clinical Significance of Thymidine Phosphorylase/plateletderived Endothelial Cell Growth Factor in Patients with Gastric Carcinoma

作　　者：王蕾[1] 胡其艳[1] 易铁男[1] 李泉[1] 黄路[1] 陈元[2] 

机构地区：[1]湖北省襄阳市中心医院肿瘤科,襄阳441021 [2]华中科技大学同济医学院附属同济医院肿瘤科,武汉430030

出　　处：《中国医药导刊》2011年第7期1235-1237,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:研究TP/PD-ECGF在胃癌中的表达情况,并对其与胃癌患者临床病理特征和预后的关系进行探讨。方法:采用免疫组化EnVision两步法检测107例胃癌组织中TP/PD-ECGF的表达,并分析其与胃癌患者临床病理特征及预后的关系。结果:胃癌患者中TP/PD-ECGF阳性表达率为71.0%。TP/PD-ECGF表达与肿瘤分期、淋巴结转移、远处转移及分化程度呈正相关。TP/PD-ECGF阳性与阴性表达患者3年、5年总生存率分别为69.04%、18.12%和88.87%、75.20%,二者差异有统计学意义(P=0.0383)。Cox比例风险模型多因素分析显示,肿瘤分期、淋巴结转移、远处转移及TP/PD-ECGF均是影响胃癌预后独立的危险因素。结论:TP/PD-ECGF在胃癌组织中呈高表达,与胃癌生长和浸润转移关系密切,可作为胃癌独立的预后因素。Objective：Thymidine phosphorylase/Platelet-derived endothelial cell growth factor （TP/PD-ECGF） has shown to be upregulated in several cancers and to play an important role in angiogenesis and invasion of solid tumors,This study was to detect the expression of TP/PD-ECGF,and investigate its influence on the clinicopahtological characteristics and the prognosis m gastric carcinoma patients. Methods：The expression of TP/PD-ECGF in 107 specimens of gastric carcinoma was examined by EnVision immunohistochemistry.The correlation of the expression of TP/PD-ECGF to the clinieopathologieal characteristics and the prognosis m gastric carcinoma patients were analyzed.Results：The positive expression rate of TP/PD-ECGF was 71.0% in gastric carcinoma.The expression of TP/PD-ECGF were positively correlated to the stage of primary tumor, lymph node metastasis,distant metastasis and histological grade.The 3-year and 5-year overall survival rates were significant lower in the patients with positive expression of TP/PD-ECGF than in those with negauve expression of TP/PD-ECGF （69.04% vs. 88.87%,18.12% vs. 75.20%,P=0.0383）.Multivariate Cox model analysis showed that the stage of primly tumor, lymph node metastasis,distant metastasis and TP/PD-ECGF were the independent prognostic factors for the patients with gastric carcinoma.Conelusion：TP/PD-ECGF is overexpressed in gastric carcinoma, and related with the growth, invasion and metastasis of gastric carcinoma,and it is an independent prognostic indicator of survival in patients with gastric carcinoma

关 键 词：胃癌 血小板衍化内皮细胞生长因子 预后 

分 类 号：R735.2[医药卫生—肿瘤]