活性维生素D对肾移植受者术后钙磷代谢平衡的影响  

Effects of Vitamin D Supplementation on the Calcium-phosphate Balance in Renal Transplant Patients

作　　者：王向阳[1] 李雄根[1] 张万帆[1] 王丽莹[1] 

机构地区：[1]深圳市人民医院肾脏内科,深圳518020

出　　处：《中国医药导刊》2011年第8期1381-1382,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:研究活性维生素D的临床应用对肾移植受者术后血钙、血磷及甲状旁腺激素(PTH)的影响。方法:回顾性分析在我院随访的肾移植且移植肾功能正常的受者54例,其中19例在肾移植术后1月开始使用活性维生素D,另35例为对照组,分析术后1年两组患者之间血钙、磷及PTH的变化。结果:与对照组相比,活性维生素D治疗组术后1年血钙水平显著性增高[(2.41±0.21)vs(2.22±0.24)mmol/L,P<0.05],血iPTH水平显著降低(65.54±26.35 vs 102.45±37.46,P<0.05),而血磷水平两组间无显著差异[(1.04±0.18)vs(0.97±0.27),P>0.05]。结论:活性维生素D的使用能有效改善肾移植受者术后血钙,磷的代谢平衡,并降低血iPTH水平,能有效预防肾移植受者术后继发性甲状旁腺功能亢进的发生。Objective：To investigate the ability of bioactive vitamin D3 supplemetation.MethodszA cross-sectional study was conducted to investigate in 54 kidney transpanlation recipiems（RTRs） with normal renal fimction （ serum crcatinine ≤1.5mg/dl）. In this study we evaluated the effects of the treatment by bioactive vitamin D3 on serum intact parathyroid hormone（iPTH）levels ,and on calcium-phospate balance in 19 RTRs and compared these results with those obtained in another group of 35 RTRs who did not recewe bioactivc vitamin D3 supplementation.Results：The biological characteristics of the two equally divided patient groups did not differ before treatment. Compared lo controls.Serum calcium concentration were significantly higher[（2,41 ± 0.21）vs. （2.18±0.24） retool/ L,P〈0.05],iPTH levels were lower[（65.54 ± 26.35 ivs （ 102.45± 37.46）pg/ml,P〈0.05]in treated patients after one year following transplant. However.serum phosphate conccnrration did not differ between two group.Conclusion： Bioactivc vitamin D3 supplemetation can be helpful to calcium-phosphate balance and improve secondary hyperparathyroidism in renal transplanlation receipiems.

关 键 词：肾移植 活性维生素D 甲状旁腺激素 

分 类 号：R977.24[医药卫生—药品] R699.2[医药卫生—药学]