SOX方案新辅助应用于进展期胃癌的化疗毒性反应观察及护理  

Observation and Nursing of Toxicitis of Sox Regimen as Nroadjuvant Chemotherapy For Advanced Gancer Palients in 37 Cases

作　　者：李娟[1] 肖西平[1] 孙晓亚[1] 

机构地区：[1]中国人民解放军总医院普通外科四病区,北京100853

出　　处：《中国医药导刊》2011年第8期1428-1429,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:通过对新辅助化疗进展期胃癌患者应用SOX方案新辅助化疗毒性反应观察,制定化疗护理对策。方法:37例进展期胃癌患者入组。化疗前肿瘤分期为Ⅲb 17例;Ⅲc16例;Ⅳ4例。化疗方案:替吉奥胶囊80mg/m^2/d,d1～14;注射用奥沙利铂130 mg/m2/d,d1,每3周重复。每2个治疗周期应用CT、EUS进行有效性评估。安全性分析依据CTCAE 3.0版本进行评估。结果:37例患者总体有效率为64.8%,疾病控制率为91.8%。31例患者进行外科手术,其中26例患者行胃癌D2手术,R0切除率为77.4%。3/4级毒性反应主要为:呕吐(10.8%);肝功能异常(8.1%);贫血(5.4%);中性粒细胞减少(5.4%);食欲减退(5.4%)。结论:通过对新辅助化疗进展期胃癌患者应用SOX方案新辅助化疗毒性反应观察,毒性反应主要以呕吐;肝功能异常;贫血;中性粒细胞减少;食欲减退多见,因此护理上应针对以上几点发生率高的毒性反应制定相应的护理计划和措施,进行有针对性地护理,使患者顺利渡过化疗期。Objective：Draw up the chemotherapy nursing plan for gastric cancer patients in progressive stage according to the toxic reaction of patients under SOX neoadjuvant chemotherapy.Methods：37 cases of progressive stage enroll.Before chemotherapy, the minor stage is that： 17 cases arc of lllb.16 cases are of IIIc;4 cases arc of IV.Chemotherapy regimcns：Gio capsules for 80mg/m2/d, d1- 14,injection of Oxatiplatin 130 mg/m2/d, dl,repeated every 3 weeks.The validity evahmtion is carried on every 2 treatment cycles by CT and EUS, and the safety analysis is based on CTCAE 3.0 Evaluation version.Results：OveraU efficiency of the 37 patients is 64.8%.and disease control rate is 91.8%.31 patients are performed the surgical operation.and among them,26 patients undergo gastric surgery D2.R0 resection rate was 77.4%.3/4 toxic reactions are：vomiting （10.8%）,liver function abnormalities（8.1%）,anemia（5.4%）,Neutrogena（5.4%）,lo ss of appetlte（ 5.4%）.Conelusion：The toxic reaction of panents in progresswe stage under SOX neoadjuvant chemotherapy ~s common m vomiting,liver dysftmction.anemia.neutropenia,and loss of appetite.Therefore,the nursingplan and measure should be drawn up against the several toxic reaction of high incidenccabove in order to make the patients cross the chemotherapy smoothly.

关 键 词：胃癌 新辅助化疗 毒性反应 护理 

分 类 号：R473.73[医药卫生—护理学]