舒血宁对冠心病慢性心力衰竭患者心功能的影响  

Effect of Shuxuening on chronic heart failure in patients with coronary heart disease

作　　者：王斯闻[1] 孟秀君[2] 王萌伟[1] 沈京莲[1] 姚风臣[3] 

机构地区：[1]中国医科大学附属第四医院急诊科,辽宁沈阳110005 [2]中国医科大学附属第四医院神经内科,辽宁沈阳110005 [3]中国医科大学附属第四医院心内科,辽宁沈阳110005

出　　处：《中国误诊学杂志》2011年第30期7322-7324,共3页Chinese Journal of Misdiagnostics

基　　金：国家"十一五"科技支撑重点项目暨辽宁省科技攻关计划重大项目(国家编号:2007BAI07A13;辽宁省编号:2004225001);辽宁省科学技术计划项目(编号:2009225040)

摘　　要：目的观察冠心病慢性心力衰竭(CHF)患者应用舒血宁注射液治疗后心肌缺血及心功能改善情况。方法将140例患者随机分为治疗组(舒血宁组)70例和对照组(常规治疗组)70例。两组常规治疗相同,治疗组在常规治疗基础上给予舒血宁注射液20ml/d,静脉滴注,疗程14d;比较两组治疗前后及组间左心室射血分数(LVEF)、心电图及胸闷症状缓解情况。结果治疗组治疗后常规12导联中ST段压低总和及ST段压低>0.5mm的导联数均明显降低(P<0.01),LVEF值显著升高(P<0.01),与对照组比较差异具有统计学意义。胸闷症状改善率,治疗组的显效率和总有效率均高于对照组(P<0.05)。结论冠心病心力衰竭患者联合应用舒血宁可以改善心肌缺血及心功能。Objective To observe the improvement of myocardial ischemia and heart function of patients with coronary heart disease combined with chronic heart failure（CHF） after treatting with Shuxuening injection. Methods 140 patients were randomly divided into treatment group （Shuxuening group 70 cases）, control group （ 70 cases）. Both groups received conventional treatment,Shuxuening group received additionally ~huxuening intravenous infusion 20 ml/d for 14 d Left ventricular ejection fraction（LVEF）,electrocardiogram and relief of chest tightness symptoms were evaluated before and after treatment. Results In Shuxuening group,the sum of ST segment depression（∑ST） and ST segment depressionS0.5 ram（N ST） of 12 lead electrocardiogram were significantly lower（P〈0.01 ） and LVEF was significantly higher （P〈0.01） compared with control group. The improvement rate of Chest tightness symptom and total efficiency rate was higher in the treatment group（ P〈0. 05 ）. Conclusion The combination treatment of Shuxuening in the heart failure patients with coronary heart disease can improve myocardial ischemia and heart function.

关 键 词：银杏素/治疗应用 冠状动脉疾病/并发症 心力衰竭 充血性/病因学 心脏/生理学 心肌缺血/并发症/药物疗法 

分 类 号：R541.4[医药卫生—心血管疾病] R541.61[医药卫生—内科学]