AT1R基因A1166C的多态性与急性心肌梗死患者冠脉病变程度的关系  

Association between angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and extent of coronary stenosis in patients with acute myocardial infarction

作　　者：彭建业[1] 张玲[1] 尹凯[2] 罗琼[1] 桂庆军[2] 

机构地区：[1]南华大学附属第二医院心内科,湖南衡阳421001 [2]南华大学诊断学教研室,湖南衡阳421001

出　　处：《心脏杂志》2011年第5期613-616,622,共5页Chinese Heart Journal

基　　金：湖南省科技厅科研基金项目资助(2007SK3092)

摘　　要：目的:研究血管紧张素Ⅱ1型受体(AT1R)基因A1166C的多态性与急性心肌梗死(AMI)患者冠脉病变程度的关系。方法:采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测105例初发AMI患者的AT1R基因A1166C的多态性。对所有患者进行冠脉造影,根据结果判定冠脉病变的支数(狭窄程度≥50%)和冠脉病变的Gensini积分。结果:AMI患者中,AC+CC基因型携带者冠脉病变的支数和Gensini积分均显著高于AA基因型携带者(P<0.05)。结论:AT1R基因A1166C的多态性与AMI患者冠脉病变程度有关。AIM：To study the relationship between the angiotensin II type 1 receptor （AT1R） gene A1166C polymorphism and the extent of coronary stenosis in patients with acute myocardial infarction （AMI）. METHODS： The A1166C polymorphism of 105 primary AMI patients was detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. All patients underwent coronary angiography, and the number of affected coronary vessels （≥50% stenosis） and the coronary Gensini score were determined by the results of coronary angiography. RESULTS： Either the number of affected coronary vessels or the coronary Gensini score in AC＋CC genotype carriers was significantly higher than in AA genotype carriers （P〈0.05）. CONCLUSION： The AT1R gene A1166C polymorphism may be related to the extent of coronary stenosis in AMI patients.

关 键 词：血管紧张素Ⅱ1型受体(AT1R) 基因多态性 急性心肌梗死 冠脉狭窄 

分 类 号：R542.22[医药卫生—心血管疾病]