青年急性冠脉综合征的危险因素  

Risk factors for young patients with acute coronary syndrome

作　　者：何华[1] 韩福生[1] 贾平[1] 刘巍[1] 崔松[1] 马临安[1] 

机构地区：[1]首都医科大学附属北京安贞医院急诊心内科,北京100029

出　　处：《心脏杂志》2011年第5期661-663,共3页Chinese Heart Journal

摘　　要：目的:通过病例对照研究探讨35岁以下青年急性冠脉综合征(ACS)的危险因素。方法:选择我院就诊的18～35岁急性心肌梗死和不稳定型心绞痛患者作为ACS组,同期就诊、年龄和性别匹配的非ACS患者作为对照组,记录两组的临床特征,包括年龄、性别、体质量指数(BMI)、吸烟史、饮酒史、是否并发高血压病、糖尿病和血脂异常、ACS类型、冠脉病变情况,然后通过单因素和多因素分析判断青年ACS的危险因素。结果:两组各入选338例患者,单因素分析表明ACS组吸烟、高血压病、糖尿病、血脂异常、肥胖、睡眠缺乏者显著高于非ACS组,进一步多因素分析表明吸烟、高血压病、糖尿病、血脂异常、肥胖、睡眠缺乏是青年ACS发病的独立危险因素,诱发青年ACS的OR值分别是2.0、2.3、2.9、2.4、3.2和1.5。结论:本研究表明除吸烟、高血压病、糖尿病、血脂异常、肥胖等因素外,睡眠缺乏也是35岁以下青年ACS患者的独立危险因素。AIM：To probe into the risk factors for acute coronary syndrome （ACS） in patients 〈35 years old. METHODS： ACS in patients aged 18-35 years old from January 2005 to August 2010 were selected as case group. Age- and gender-matched non-ACS patients treated at our hospital during the same period were selected as the control group. Clinical characteristics in the two groups were investigated and recorded, and single-factor analysis and multivariate analysis were performed to analyze the risk factors for ACS in patients 〈35 years old. RESULTS： There were 338 included cases in each group. Single-factor analysis indicated that the number of patients with smoking, concomitant essential hypertension, diabetes mellitus, dyslipidemia, increased BMI, and sleep deprivation in the ACS group was higher than in the non-ACS group, and the multivariate analysis indicated that the above-mentioned factors were independent risk factors for ACS in patients 〈35 years old, with OR values, respectively, 2.0, 2.3, 2.9, 2.4, 3.2 and 1.5. CONCLUSION： In addition to smoking, concomitant essential hypertension, diabetes mellitus, dyslipidemia, and increased BMI along with sleep deprivation are also independent risk factors for ACS in patients 〈35 years old.

关 键 词：青年 急性冠脉综合征 危险因素 睡眠缺乏 

分 类 号：R541.4[医药卫生—心血管疾病]